General information | DisProt: | DP00027 | Name: | Negative regulator of flagellin synthesis | Synonym(s): | FLGM_SALTY
Anti-sigma-28 factor
FlgM
| First appeared in release: | Release 1.0 (08/01/2003) | UniProt: | P26477 | UniGene: | | SwissProt: | FLGM_SALTY | TrEMBL: | | NCBI (GI): | 120306 | Source organism: | Salmonella typhimurium | Sequence length: | 97 | Percent disordered: | 100% | Homologues: | |
Native sequence |
10 20 30 40 50 60 | | | | | | MSIDRTSPLK PVSTVQTRET SDTPVQKTRQ EKTSAATSAS VTLSDAQAKL MQPGVSDINM - 60 ERVEALKTAI RNGELKMDTG KIADSLIREA QSYLQSK
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Functional narrative |
Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of fliA by directly binding to fliA.
The N-terminal domain is essential for export and the C-terminal domain possess the fliA binding site.
Belongs to the flgM family.
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Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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Region 1 | Type: | Disordered | Name: | | Location: | 1 - 97 | Length: | 97 | Region sequence: |
MSIDRTSPLKPVSTVQTRETSDTPVQKTRQEKTSAATSASVTLSDAQAKLMQPGVSDINM ERVEALKTAIRNGELKMDTGKIADSLIREAQSYLQSK | Modification type: | Native
| PDB: | | Structural/functional type: | Function arises via a disorder to order transition | Functional classes: | | Functional subclasses: | Protein inhibitor
Protein-protein binding
| Detection methods:
- Nuclear magnetic resonance (NMR) (298 K; pH: 6.2; D2O 5 %; General Electric Omega 500 MHz (spectrometer); NaCl 10 mM; NaN3 0.02 %; protein (sample) 10 mM; sodium phosphate (buffer) 10 mM)
| References:
- Daughdrill GW, Chadsey MS, Karlinsey JE, Hughes KT, Dahlquist FW. "The C-terminal half of the anti-sigma factor, FlgM, becomes structured when bound to its target, sigma 28." Nat Struct Biol. 1997; 4(4): 285-91. PubMed: 9095196
| Comments:
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References |
- Daughdrill GW, Chadsey MS, Karlinsey JE, Hughes KT, Dahlquist FW. "The C-terminal half of the anti-sigma factor, FlgM, becomes structured when bound to its target, sigma 28." Nat Struct Biol. 1997; 4(4): 285-91. PubMed: 9095196
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Comments |
AV 7-29-2010 PubMed: 9095196
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