| General information | | DisProt: | DP00035 | | Name: | Guanine nucleotide-binding protein G(i), alpha-1 subunit | | Synonym(s): | GNAI1_RAT
Adenylate cyclase-inhibiting G alpha protein
G protein alpha G(i)
| | First appeared in release: | Release 1.0 (08/01/2003) | | UniProt: | P10824 | | UniGene: | Rn.11391 | | SwissProt: | GNAI1_RAT | | TrEMBL: | | | NCBI (GI): | 121020 | | Source organism: | Rattus norvegicus (Rat) | | Sequence length: | 354 | | Percent disordered: | 12% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MGCTLSAEDK AAVERSKMID RNLREDGEKA AREVKLLLLG AGESGKSTIV KQMKIIHEAG - 60
YSEEECKQYK AVVYSNTIQS IIAIIRAMGR LKIDFGDAAR ADDARQLFVL AGAAEEGFMT - 120
AELAGVIKRL WKDSGVQACF NRSREYQLND SAAYYLNDLD RIAQPNYIPT QQDVLRTRVK - 180
TTGIVETHFT FKDLHFKMFD VGGQRSERKK WIHCFEGVTA IIFCVALSDY DLVLAEDEEM - 240
NRMHESMKLF DSICNNKWFT DTSIILFLNK KDLFEEKIKK SPLTICYPEY AGSNTYEEAA - 300
AYIQCQFEDL NKRKDTKEIY THFTCATDTK NVQFVFDAVT DVIIKNNLKD CGLF
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| Functional narrative |
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | N-terminal | | Location: | 1 - 31 | | Length: | 31 | | Region sequence: |
MGCTLSAEDKAAVERSKMIDRNLREDGEKAA | | Modification type: | Native
| | PDB: | | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Molecular recognition effectors
| | Functional subclasses: | | Detection methods:
- X-ray crystallography (280 K; CHESS F1 (beam); wavelength 0.91 A)
| References:
- Coleman DE, Berghuis AM, Lee E, Linder ME, Gilman AG, Sprang SR. "Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis." Science. 1994; 265(5177): 1405-12. PubMed: 8073283
| Comments:
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| Region 2 | | Type: | Disordered | | Name: | C-terminal | | Location: | 344 - 354 | | Length: | 11 | | Region sequence: |
IKNNLKDCGLF | | Modification type: | Native
| | PDB: | | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Molecular recognition effectors
| | Functional subclasses: | | Detection methods:
- X-ray crystallography (280 K; CHESS F1 (beam); wavelength 0.91 A)
| References:
- Coleman DE, Berghuis AM, Lee E, Linder ME, Gilman AG, Sprang SR. "Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis." Science. 1994; 265(5177): 1405-12. PubMed: 8073283
| Comments:
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| References |
- Coleman DE, Berghuis AM, Lee E, Linder ME, Gilman AG, Sprang SR. "Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis." Science. 1994; 265(5177): 1405-12. PubMed: 8073283
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| Comments |
Av 6-28-2010 PubMed: 8073283
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