DP00090: Voltage-gated potassium channel subunit beta-1 [Isoform KvB1.1]FASTA viewXML view

General information
DisProt:DP00090
Name:Voltage-gated potassium channel subunit beta-1 [Isoform KvB1.1]
Synonym(s):KCAB1_HUMAN
K(+) channel subunit beta-1
Kv-beta-1
Potassium channel shaker chain beta 1a
Potassium voltage-gated channel, shaker-related subfamily, beta member 1, isoform 3
First appeared in release:Release 3.0 (02/17/2006)
UniProt:Q14722-2
UniGene:Hs.654519
SwissProt: KCAB1_HUMAN
TrEMBL:  
NCBI (GI): 18202500
Source organism:Homo sapiens (Human)
Sequence length:401
Percent disordered:15%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MQVSIACTEH NLKSRNGEDR LLSKQSSTAP NVVNAARAKF RTVAIIARSL GTFTPQHHIS - 60
LKESTAKQTG MKYRNLGKSG LRVSCLGLGT WVTFGGQISD EVAERLMTIA YESGVNLFDT - 120
AEVYAAGKAE VILGSIIKKK GWRRSSLVIT TKLYWGGKAE TERGLSRKHI IEGLKGSLQR - 180
LQLEYVDVVF ANRPDSNTPM EEIVRAMTHV INQGMAMYWG TSRWSAMEIM EAYSVARQFN - 240
MIPPVCEQAE YHLFQREKVE VQLPELYHKI GVGAMTWSPL ACGIISGKYG NGVPESSRAS - 300
LKCYQWLKER IVSEEGRKQQ NKLKDLSPIA ERLGCTLPQL AVAWCLRNEG VSSVLLGSST - 360
PEQLIENLGA IQVLPKMTSH VVNEIDNILR NKPYSKKDYR S

Region 1: 1-62

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:N-terminal domain
Location:1 - 62
Length:62
Region sequence:

MQVSIACTEHNLKSRNGEDRLLSKQSSTAPNVVNAARAKFRTVAIIARSLGTFTPQHHIS
LK

Modification type: Fragment
Native
PDB:  
Structural/functional type: Function arises from the disordered state
Functional classes: Entropic chain
Functional subclasses: Flexible linkers/spacers
Detection methods:
  1. Nuclear magnetic resonance (NMR) (283 K; Bruker DMX 800 (spectrometer); Bruker DRX 600 (spectrometer); D2O 99.9 %)

References:
  1. Wissmann R, Baukrowitz T, Kalbacher H, Kalbitzer HR, Ruppersberg JP, Pongs O, Antz C, Fakler B. "NMR structure and functional characteristics of the hydrophilic N terminus of the potassium channel beta-subunit Kvbeta1.1." J Biol Chem. 1999; 274(50): 35521-5. PubMed: 10585425

Comments:
 



Comments


Additional UniGene ID: Hs.703187


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