DP00095: Tyrosyl-tRNA synthetaseFASTA viewXML view

General information
DisProt:DP00095
Name:Tyrosyl-tRNA synthetase
Synonym(s):SYY_BACST
Tyrosine-tRNA ligase
TyrRS
Tyrosine-transfer ribonucleate synthetase
Tyrosine translase
EC=6.1.1.1
First appeared in release:Release 1.0 (08/01/2003)
UniProt:P00952
UniGene: 
SwissProt: SYY_BACST
TrEMBL:  
NCBI (GI): 135197
Source organism:Bacillus stearothermophilus (Geobacillus stearothermophilus)
Sequence length:419
Percent disordered:24%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MDLLAELQWR GLVNQTTDED GLRKLLNEER VTLYCGFDPT ADSLHIGHLA TILTMRRFQQ - 60
AGHRPIALVG GATGLIGDPS GKKSERTLNA KETVEAWSAR IKEQLGRFLD FEADGNPAKI - 120
KNNYDWIGPL DVITFLRDVG KHFSVNYMMA KESVQSRIET GISFTEFSYM MLQAYDFLRL - 180
YETEGCRLQI GGSDQWGNIT AGLELIRKTK GEARAFGLTI PLVTKADGTK FGKTESGTIW - 240
LDKEKTSPYE FYQFWINTDD RDVIRYLKYF TFLSKEEIEA LEQELREAPE KRAAQKTLAE - 300
EVTKLVHGEE ALRQAIRISE ALFSGDIANL TAAEIEQGFK DVPSFVHEGG DVPLVELLVS - 360
AGISPSKRQA REDIQNGAIY VNGERLQDVG AILTAEHRLE GRFTVIRRGK KKYYLIRYA

Region 1: 320-419

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:C-terminal domain
Location:320 - 419
Length:100
Region sequence:

EALFSGDIANLTAAEIEQGFKDVPSFVHEGGDVPLVELLVSAGISPSKRQAREDIQNGAI
YVNGERLQDVGAILTAEHRLEGRFTVIRRGKKKYYLIRYA

Modification type:  
PDB: 2TS1:A
Structural/functional type: Function arises via a disorder to order transition
Functional classes:  
Functional subclasses: Protein-tRNA binding
Substrate/ligand binding
Detection methods:
  1. X-ray crystallography (2.3 A)

  2. Nuclear magnetic resonance (NMR) (time scale 1e+08 Hz)

References:
  1. Brick P, Bhat TN, Blow DM. "Structure of tyrosyl-tRNA synthetase refined at 2.3 A resolution. Interaction of the enzyme with the tyrosyl adenylate intermediate." J Mol Biol. 1989; 208(1): 83-98. PubMed: 2504923

  2. Guijarro JI, Pintar A, Prochnicka-Chalufour A, Guez V, Gilquin B, Bedouelle H, Delepierre M. "Structure and dynamics of the anticodon arm binding domain of Bacillus stearothermophilus Tyrosyl-tRNA synthetase." Structure (Camb). 2002; 10(3): 311-7. PubMed: 12005430

Comments:
 


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