Annotation for this protein is in progress - please check future releases for more complete information


DP00125: SomatoliberinFASTA viewXML view

General information
DisProt:DP00125
Name:Somatoliberin
Synonym(s):SLIB_BOVIN
Growth hormone-releasing factor
GRF
Growth hormone-releasing hormone
GHRH
First appeared in release:Release 3.0 (02/17/2006)
UniProt:P63292
UniGene:Bt.45045
SwissProt: SLIB_BOVIN
TrEMBL:  
NCBI (GI): 54039610
Source organism:Bos taurus (Bovine)
Sequence length:106
Percent disordered:27%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MLLWVFFLVT LTLSSGSHGS LPSQPLRIPR YADAIFTNSY RKVLGQLSAR KLLQDIMNRQ - 60
QGERNQEQGA KVRLGRQVDG VWTDQQQMAL ESTLVSLLQE RRNSQG

Region 1: 31-59

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:U-90600F
Location:31 - 59
Length:29
Region sequence:

YADAIFTNSYRKVLGQLSARKLLQDIMNR

Modification type: Engineered
Fragment
Mutant
PDB:  
Structural/functional type: Function arises via a disorder to order transition
Functional classes:  
Functional subclasses:  
Detection methods:
  1. Fourier transform infrared spectroscopy (FTIR), aka infrared spectroscopy) (323 K; pH: 5.6; Protein (100 mg/ml))

  2. Fourier transform infrared spectroscopy (FTIR), aka infrared spectroscopy) (513 K; pH: 5.6; Protein (100 mg/ml))

  3. Fourier transform infrared spectroscopy (FTIR), aka infrared spectroscopy) (297 K; pH: 5.6; Protein (100 mg/ml))

  4. Fourier transform infrared spectroscopy (FTIR), aka infrared spectroscopy) (278 K; pH: 5.6; Protein (100 mg/ml))

  5. Raman optical activity (313 K; )
References:
  1. Sarver RW Jr, Friedman AR, Thamann TJ. "Spectroscopic studies on the conformational transitions of a bovine growth hormone releasing factor analog." Spectrochim Acta A Mol Biomol Spectrosc. 1997; 53A(11): 1889-900. PubMed: 9375414
Comments:
U-90699F is an analog of the bovine growth hormone releasing factor. It is a fragment that contains the following substitutions: Ile32, Ser38, Ala45, Leu57, and Ser58. It also has a C-terminal tag of Hse-NH-ethyl x Ch3COOH.




References

  1. Esch F, Bohlen P, Ling N, Brazeau P, Guillemin R. "Isolation and characterization of the bovine hypothalamic growth hormone releasing factor." Biochem Biophys Res Commun. 1983; 117(3): 772-9. PubMed: 6421287


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