Annotation for this protein is in progress - please check future releases for more complete information


DP00129: Transcription factor p65FASTA viewXML view

General information
DisProt:DP00129
Name:Transcription factor p65
Synonym(s):TF65_MOUSE
Nuclear factor NF-kappa-B p65 subunit
First appeared in release:Release 2.0 (02/14/2005)
UniProt:Q04207
UniGene:Mm.249966
SwissProt: TF65_MOUSE
TrEMBL:  
NCBI (GI): 417926
Source organism:Mus musculus (Mouse)
Sequence length:549
Percent disordered:55%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MDDLFPLIFP SEPAQASGPY VEIIEQPKQR GMRFRYKCEG RSAGSIPGER STDTTKTHPT - 60
IKINGYTGPG TVRISLVTKD PPHRPHPHEL VGKDCRDGYY EADLCPDRSI HSFQNLGIQC - 120
VKKRDLEQAI SQRIQTNNNP FHVPIEEQRG DYDLNAVRLC FQVTVRDPAG RPLLLTPVLS - 180
HPIFDNRAPN TAELKICRVN RNSGSCLGGD EIFLLCDKVQ KEDIEVYFTG PGWEARGSFS - 240
QADVHRQVAI VFRTPPYADP SLQAPVRVSM QLRRPSDREL SEPMEFQYLP DTDDRHRIEE - 300
KRKRTYETFK SIMKKSPFNG PTEPRPPTRR IAVPTRNSTS VPKPAPQPYT FPASLSTINF - 360
DEFSPMLLPS GQISNQALAL APSSAPVLAQ TMVPSSAMVP LAQPPAPAPV LTPGPPQSLS - 420
APVPKSTQAG EGTLSEALLH LQFDADEDLG ALLGNSTDPG VFTDLASVDN SEFQQLLNQG - 480
VSMSHSTAEP MLMEYPEAIT RLVTGSQRPP DPAPTPLGTS GLPNGLSGDE DFSSIADMDF - 540
SALLSQISS

Region 3: 19-304 Region 2: 309-326 Region 1: 321-326

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:321 - 326
Length:6
Region sequence:

PTEPRP

Modification type: Complex
Engineered
Fragment
PDB: 1K3Z:A
Structural/functional type: Relationship to function unknown
Functional classes: Unknown
Functional subclasses: Unknown
Detection methods:
  1. X-ray crystallography
References:
  1. Malek S, Huang DB, Huxford T, Ghosh S, Ghosh G. "X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex." J Biol Chem. 2003; 278(25): 23094-100. PubMed: 12686541
Comments:
 



Region 2
Type:Disordered
Name: 
Location:309 - 326
Length:18
Region sequence:

FKSIMKKSPFNGPTEPRP

Modification type: Complex
Engineered
Fragment
PDB: 1K3Z:B
Structural/functional type: Relationship to function unknown
Functional classes: Unknown
Functional subclasses: Unknown
Detection methods:
  1. X-ray crystallography
References:
  1. Malek S, Huang DB, Huxford T, Ghosh S, Ghosh G. "X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex." J Biol Chem. 2003; 278(25): 23094-100. PubMed: 12686541
Comments:
 



Region 3
Type:Disordered
Name: 
Location:19 - 304
Length:286
Region sequence:

PYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVT
KDPPHRPHPHELVGKDCRDGYYEADLCPDRSIHSFQNLGIQCVKKRDLEQAISQRIQTNN
NPFHVPIEEQRGDYDLNAVRLCFQVTVRDPAGRPLLLTPVLSHPIFDNRAPNTAELKICR
VNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYA
DPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKR

Modification type: Fragment
Native
PDB: 1IKN:A
Structural/functional type: Relationship to function unknown
Functional classes: Molecular recognition effectors
Functional subclasses: Nuclear localization
Detection methods:
 
References:
  1. Huang DB, Huxford T, Chen YQ, Ghosh G. "The role of DNA in the mechanism of NFkappaB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits." Structure. 1997; 5(11): 1427-36. PubMed: 9384558
Comments:
 


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