10         20         30         40         50         60
         |          |          |          |          |          |
MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPDR QIPFHDVRFP PPVGYNKDIN - 60
ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD ATYNEIVTIE RLRSVNPNKP - 120
ATKDTFHKIK LDVPEDLRQM CAKEAAHKDF KKAVGAFSVT YDPENYQLVI LSINEVTSKR - 180
AHMLIDMHFR SLRTKLSLIM RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN - 240
IQQARKVPGV TAIDLDEDTC TFHIYGEDQD AVKKARSFLE FAEDVIQVPR NLVGKVIGKN - 300
GKLIQEIVDK SGVVRVRIEA ENEKNVPQEE EIMPPNSLPS NNSRVGPNAP EEKKHLDIKE - 360
NSTHFSQPNS TKVQRVLVAS SVVAGESQKP ELKAWQGMVP FVFVGTKDSI ANATVLLDYH - 420
LNYLKEVDQL RLERLQIDEQ LRQIGASSRP PPNRTDKEKS YVTDDGQGMG RGSRPYRNRG - 480
HGRRGPGYTS GTNSEASNAS ETESDHRDEL SDWSLAPTEE ERESFLRRGD GRRRGGGGRG - 540
QGGRGRGGGF KGNDDHSRTD NRPRNPREAK GRTTDGSLQI RVDCNNERSV HTKTLQNTSS - 600
EGSRLRTGKD RNQKKEKPDS VDGQQPLVNG VP

"FMR1 is an RNA-binding protein that is either absent or mutated in patients affected by the fragile X syndrome, the most common inherited cause of mental retardation in humans.... The disease is characterized by mental retardation of variable severity, autistic behavior, macroorchidism in adult males, characteristic facial deformity and hyperextensible joints.... Appearance of the syndrome correlates with the presence in the FMR1 gene of a large trinucleotide expansion (CGG) and with hypermethylation of a CpG island within the promoter region. The length of the trinucleotide expansion correlates with clinical severity of the effect. In normal individuals, the FMR1 gene encodes an RNA-binding protein, FMR1. Although the full-length FMR1 protein is a 632-aminoacid protein, several shorter forms have been observed in vivo as a result of alternative splicing of several of the 17 exons present in the gene.... Sequence analysis of the FMR family shows the presence of three potential RNA-binding domains: an RGG motif and two K-homologous (KH) modules. The KH module is an evolutionarily conserved sequence motif of about 70 amino acids." (Adinolfi et al. 1999)