General information | DisProt: | DP00138 | Name: | Parathyroid hormone-related protein | Synonym(s): | PTHR_HUMAN
PTH-rP
PTHrP
PTHrP[1-36][cleavage product 1]
PTHrP[38-94][cleavage product 2]
Osteostatin [cleavage product 3]
PTHrP[107-139]
| First appeared in release: | Release 1.0 (08/01/2003) | UniProt: | P12272 | UniGene: | Hs.591159 | SwissProt: | PTHR_HUMAN | TrEMBL: | | NCBI (GI): | 131542 | Source organism: | Homo sapiens (Human) | Sequence length: | 177 | Percent disordered: | 10% | Homologues: | |
Native sequence |
10 20 30 40 50 60 | | | | | | MQRRLVQQWS VAVFLLSYAV PSCGRSVEGL SRRLKRAVSE HQLLHDKGKS IQDLRRRFFL - 60 HHLIAEIHTA EIRATSEVSP NSKPSPNTKN HPVRFGSDDE GRYLTQETNK VETYKEQPLK - 120 TPGKKKKGKP GKRKEQEKKK RRTRSAWLDS GVTGSGLEGD HLSDTSTTSL ELDSRRH
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Functional narrative |
Parathyroid hormone-related protein precursor (PTHrP) is similar to parathyroid hormone, however it is produced in almost all types of tissues. It is involved in many physiological processes, including lactation, calcium transport, and signaling. PTHrP interacts with various receptor binding proteins including the G-protein-coupled receptor. PTHrP is produced by tumors associated with humoral hypercalcemia of malignancy (HHM). The first disordered region is thought to function in a signal transduction pathway that initiates a cascade similar to parathyroid hormone. The disordered regions near the N-terminus are involved in protein-protein interactions with G-protein-coupled receptors.
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Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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Region 1 | Type: | Disordered - Extended | Name: | | Location: | 1 - 4 | Length: | 4 | Region sequence: |
MQRR | Modification type: | Engineered
Fragment
| PDB: | | Structural/functional type: | Relationship to function unknown | Functional classes: | Molecular assembly
Molecular recognition effectors
| Functional subclasses: | Protein-protein binding
Substrate/ligand binding
| Detection methods:
- Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 5.1; )
- Nuclear magnetic resonance (NMR) (277 K; pH: 5.1; )
| References:
- Weidler M, Marx UC, Seidel G, Schafer W, Hoffmann E, Esswein A, Rosch P. "The structure of human parathyroid hormone-related protein(1-34) in near-physiological solution." FEBS Lett. 1999; 444(2-3): 239-244. PubMed: 10050767
- Willis KJ. "Interaction with model membrane systems induces secondary structure in amino-terminal fragments of parathyroid hormone related protein." Int J Pept Protein Res. 1994; 43(1): 23-28. PubMed: 8138348
| Comments:
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Region 2 | Type: | Disordered - Extended | Name: | | Location: | 9 - 15 | Length: | 7 | Region sequence: |
WSVAVFL | Modification type: | Engineered
Fragment
| PDB: | | Structural/functional type: | Function arises via a disorder to order transition | Functional classes: | Molecular assembly
Entropic chain
| Functional subclasses: | Flexible linkers/spacers
| Detection methods:
- Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 5.1; )
- Nuclear magnetic resonance (NMR) (277 K; pH: 5.1; )
| References:
- Weidler M, Marx UC, Seidel G, Schafer W, Hoffmann E, Esswein A, Rosch P. "The structure of human parathyroid hormone-related protein(1-34) in near-physiological solution." FEBS Lett. 1999; 444(2-3): 239-244. PubMed: 10050767
- Willis KJ. "Interaction with model membrane systems induces secondary structure in amino-terminal fragments of parathyroid hormone related protein." Int J Pept Protein Res. 1994; 43(1): 23-28. PubMed: 8138348
| Comments:
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Region 3 | Type: | Disordered - Extended | Name: | | Location: | 28 - 34 | Length: | 7 | Region sequence: |
EGLSRRL | Modification type: | Engineered
Fragment
| PDB: | | Structural/functional type: | Relationship to function unknown | Functional classes: | Molecular recognition effectors
Molecular assembly
| Functional subclasses: | Substrate/ligand binding
Protein-protein binding
| Detection methods:
- Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 5.1; )
- Nuclear magnetic resonance (NMR) (277 K; pH: 5.1; )
| References:
- Weidler M, Marx UC, Seidel G, Schafer W, Hoffmann E, Esswein A, Rosch P. "The structure of human parathyroid hormone-related protein(1-34) in near-physiological solution." FEBS Lett. 1999; 444(2-3): 239-244. PubMed: 10050767
- Willis KJ. "Interaction with model membrane systems induces secondary structure in amino-terminal fragments of parathyroid hormone related protein." Int J Pept Protein Res. 1994; 43(1): 23-28. PubMed: 8138348
| Comments:
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Comments |
Disordered regions are not associated with any of the cleavage products.
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