DP00172: POU domain class 2-associating factor 1FASTA viewXML view

General information
DisProt:DP00172
Name:POU domain class 2-associating factor 1
Synonym(s):OBF1_HUMAN
B-cell-specific coactivator OBF-1
OCT-binding factor 1
OBF-1
BOB-1
OCA-B
First appeared in release:Release 2.0 (02/14/2005)
UniProt:Q16633
UniGene:Hs.654525
SwissProt: OBF1_HUMAN
TrEMBL:  
NCBI (GI): 2833276
Source organism:Homo sapiens (Human)
Sequence length:256
Percent disordered:9%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MLWQKPTAPE QAPAPARPYQ GVRVKEPVKE LLRRKRGHAS SGAAPAPTAV VLPHQPLATY - 60
TTVGPSCLDM EGSVSAVTEE AALCAGWLSQ PTPATLQPLA PWTPYTEYVP HEAVSCPYSA - 120
DMYVQPVCPS YTVVGPSSVL TYASPPLITN VTTRSSATPA VGPPLEGPEH QAPLTYFPWP - 180
QPLSTLPTST LQYQPPAPAL PGPQFVQLPI SIPEPVLQDM EDPRRAASSL TIDKLLLEEE - 240
DSDAYALNHT LSVEGF



Functional narrative    

POU domain class 2, associating factor 1 interacts directly with Oct-1 or Oct-2 and an octomer DNA sequence to stimulate and assist in immunoglobulin transcription and B-cell differentiation. The presence of this protein in large quantities is required for adequate response by B-cells to antigens. A deficiency of this protein is associated with immune system failure.

Region 1: 1-15 Region 2: 1-16 Region 3: 38-44 Region 4: 39-44

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered - Extended
Name: 
Location:1 - 15
Length:15
Region sequence:

MLWQKPTAPEQAPAP

Modification type: Complex
Engineered
Fragment
PDB: 1CQT:I
Structural/functional type: Function arises from the disordered state
Functional classes: Molecular assembly
Functional subclasses: Protein-DNA binding
Protein-protein binding
Detection methods:
  1. X-ray crystallography
References:
  1. Chasman D, Cepek K, Sharp PA, Pabo CO. "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface." Genes Dev. 1999; 13(20): 2650-7. PubMed: 10541551
Comments:
 



Region 2
Type:Disordered - Extended
Name: 
Location:1 - 16
Length:16
Region sequence:

MLWQKPTAPEQAPAPA

Modification type: Complex
Engineered
Fragment
PDB: 1CQT:J
Structural/functional type: Function arises from the disordered state
Functional classes: Molecular assembly
Functional subclasses: Protein-DNA binding
Protein-protein binding
Detection methods:
  1. X-ray crystallography
References:
  1. Chasman D, Cepek K, Sharp PA, Pabo CO. "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface." Genes Dev. 1999; 13(20): 2650-7. PubMed: 10541551
Comments:
 



Region 3
Type:Disordered - Extended
Name: 
Location:38 - 44
Length:7
Region sequence:

HASSGAA

Modification type: Complex
Engineered
Fragment
PDB: 1CQT:I
Structural/functional type: Function arises from the disordered state
Functional classes: Molecular assembly
Functional subclasses: Protein-DNA binding
Protein-protein binding
Detection methods:
  1. X-ray crystallography
References:
  1. Chasman D, Cepek K, Sharp PA, Pabo CO. "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface." Genes Dev. 1999; 13(20): 2650-7. PubMed: 10541551
Comments:
 



Region 4
Type:Disordered - Extended
Name: 
Location:39 - 44
Length:6
Region sequence:

ASSGAA

Modification type: Complex
Engineered
Fragment
PDB: 1CQT:J
Structural/functional type: Function arises from the disordered state
Functional classes: Molecular assembly
Functional subclasses: Protein-DNA binding
Protein-protein binding
Detection methods:
  1. X-ray crystallography
References:
  1. Chasman D, Cepek K, Sharp PA, Pabo CO. "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface." Genes Dev. 1999; 13(20): 2650-7. PubMed: 10541551
Comments:
 



References

  1. Chang JF, Phillips K, Lundback T, Gstaiger M, Ladbury JE, Luisi B. "Oct-1 POU and octamer DNA co-operate to recognise the Bob-1 transcription co-activator via induced folding." J Mol Biol. 1999; 288(5): 941-52. PubMed: 10329190


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