General information | DisProt: | DP00193 | Name: | Beta-lactoglobulin | Synonym(s): | LACB_BOVIN
Beta-LG
Bos d 5
| First appeared in release: | Release 2.0 (02/14/2005) | UniProt: | P02754 | UniGene: | Bt.385 | SwissProt: | LACB_BOVIN | TrEMBL: | | NCBI (GI): | 125910 | Source organism: | Bos taurus (Cow) | Sequence length: | 178 | Percent disordered: | 100% | Homologues: | |
Native sequence |
10 20 30 40 50 60 | | | | | | MKCLLLALAL TCGAQALIVT QTMKGLDIQK VAGTWYSLAM AASDISLLDA QSAPLRVYVE - 60 ELKPTPEGDL EILLQKWENG ECAQKKIIAE KTKIPAVFKI DALNENKVLV LDTDYKKYLL - 120 FCMENSAEPE QSLACQCLVR TPEVDDEALE KFDKALKALP MHIRLSFNPT QLEEQCHI
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Functional narrative |
Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
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Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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Region 1 | Type: | Disordered - Molten Globule | Name: | | Location: | 1 - 178 | Length: | 178 | Region sequence: |
MKCLLLALALTCGAQALIVTQTMKGLDIQKVAGTWYSLAMAASDISLLDAQSAPLRVYVE ELKPTPEGDLEILLQKWENGECAQKKIIAEKTKIPAVFKIDALNENKVLVLDTDYKKYLL FCMENSAEPEQSLACQCLVRTPEVDDEALEKFDKALKALPMHIRLSFNPTQLEEQCHI | Modification type: | Native
| PDB: | | Structural/functional type: | Relationship to function unknown | Functional classes: | Unknown
| Functional subclasses: | Unknown
| Detection methods:
- Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 1.5; potasium cirate (buffer) 10 mM)
- Size exclusion/gel filtration chromatography (277 K; pH: 1.5; HCl-KCl (buffer) 100 mM)
- Analytical ultracentrifugation (pH: 1.5; HCl-KCl (buffer) 100 mM)
| References:
- Ikeguchi M, Kato S, Shimizu A, Sugai S. "Molten globule state of equine beta-lactoglobulin." Proteins. 1997; 27(4): 567-75. PubMed: 9141136
| Comments:
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Comments |
Beta-lactoglobulin has a compact globular structure at neutral pH.
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