Annotation for this protein is in progress - please check future releases for more complete information



DP00193: Beta-lactoglobulinFASTA viewXML view

General information
DisProt:DP00193
Name:Beta-lactoglobulin
Synonym(s):LACB_BOVIN
Beta-LG
Bos d 5
First appeared in release:Release 2.0 (02/14/2005)
UniProt:P02754
UniGene:Bt.385
SwissProt: LACB_BOVIN
TrEMBL:  
NCBI (GI): 125910
Source organism:Bos taurus (Cow)
Sequence length:178
Percent disordered:100%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MKCLLLALAL TCGAQALIVT QTMKGLDIQK VAGTWYSLAM AASDISLLDA QSAPLRVYVE - 60
ELKPTPEGDL EILLQKWENG ECAQKKIIAE KTKIPAVFKI DALNENKVLV LDTDYKKYLL - 120
FCMENSAEPE QSLACQCLVR TPEVDDEALE KFDKALKALP MHIRLSFNPT QLEEQCHI



Functional narrative    

Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.

Region 1: 1-178

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered - Molten Globule
Name: 
Location:1 - 178
Length:178
Region sequence:

MKCLLLALALTCGAQALIVTQTMKGLDIQKVAGTWYSLAMAASDISLLDAQSAPLRVYVE
ELKPTPEGDLEILLQKWENGECAQKKIIAEKTKIPAVFKIDALNENKVLVLDTDYKKYLL
FCMENSAEPEQSLACQCLVRTPEVDDEALEKFDKALKALPMHIRLSFNPTQLEEQCHI

Modification type: Native
PDB:  
Structural/functional type: Relationship to function unknown
Functional classes: Unknown
Functional subclasses: Unknown
Detection methods:
  1. Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 1.5; potasium cirate (buffer) 10 mM)

  2. Size exclusion/gel filtration chromatography (277 K; pH: 1.5; HCl-KCl (buffer) 100 mM)

  3. Analytical ultracentrifugation (pH: 1.5; HCl-KCl (buffer) 100 mM)

References:
  1. Ikeguchi M, Kato S, Shimizu A, Sugai S. "Molten globule state of equine beta-lactoglobulin." Proteins. 1997; 27(4): 567-75. PubMed: 9141136

Comments:
 



Comments


Beta-lactoglobulin has a compact globular structure at neutral pH.


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