Annotation for this protein is in progress - please check future releases for more complete information


DP00210: Growth factor receptor-bound protein 2FASTA viewXML view

General information
DisProt:DP00210
Name:Growth factor receptor-bound protein 2
Synonym(s):GRB2_HUMAN
Adapter protein GRB2
SH2/SH3 adapter GRB2
Protein Ash
First appeared in release:Release 2.1 (03/14/2005)
UniProt:P62993
UniGene:Hs.444356
SwissProt: GRB2_HUMAN
TrEMBL:  
NCBI (GI): 51702266
Source organism:Homo sapiens
Sequence length:217
Percent disordered:4%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW - 60
FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL - 120
WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EDGELGFRRG - 180
DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV

Region 1: 58-59 Region 2: 153-159

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:58 - 59
Length:2
Region sequence:

HP

Modification type: Native
PDB:  
Structural/functional type: Function arises from the disordered state
Functional classes: Entropic chain
Functional subclasses: Flexible linkers/spacers
Detection methods:
  1. Nuclear magnetic resonance (NMR)
References:
  1. Yuzawa S, Yokochi M, Hatanaka H, Ogura K, Kataoka M, Miura K, Mandiyan V, Schlessinger J, Inagaki F. "Solution structure of Grb2 reveals extensive flexibility necessary for target recognition." J Mol Biol. 2001; 306(3): 527-37. PubMed: 11178911
Comments:
 



Region 2
Type:Disordered
Name: 
Location:153 - 159
Length:7
Region sequence:

QVPQQPT

Modification type: Native
PDB:  
Structural/functional type: Function arises from the disordered state
Functional classes: Entropic chain
Functional subclasses: Flexible linkers/spacers
Detection methods:
  1. Nuclear magnetic resonance (NMR)
References:
  1. Yuzawa S, Yokochi M, Hatanaka H, Ogura K, Kataoka M, Miura K, Mandiyan V, Schlessinger J, Inagaki F. "Solution structure of Grb2 reveals extensive flexibility necessary for target recognition." J Mol Biol. 2001; 306(3): 527-37. PubMed: 11178911
Comments:
 



Comments


Additional UniGene: Hs.708119


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