Annotation for this protein is in progress - please check future releases for more complete information


DP00221: InvolucrinFASTA viewXML view

General information
DisProt:DP00221
Name:Involucrin
Synonym(s):INVO_HUMAN
First appeared in release:Release 2.0 (02/14/2005)
UniProt:P07476
UniGene:Hs.516439
SwissProt: INVO_HUMAN
TrEMBL:  
NCBI (GI): 254763301
Source organism:Homo sapiens (Human)
Sequence length:585
Percent disordered:10%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MSQQHTLPVT LSPALSQELL KTVPPPVNTH QEQMKQPTPL PPPCQKVPVE LPVEVPSKQE - 60
EKHMTAVKGL PEQECEQQQK EPQEQELQQQ HWEQHEEYQK AENPEQQLKQ EKTQRDQQLN - 120
KQLEEEKKLL DQQLDQELVK RDEQLGMKKE QLLELPEQQE GHLKHLEQQE GQLKHPEQQE - 180
GQLELPEQQE GQLELPEQQE GQLELPEQQE GQLELPEQQE GQLELPQQQE GQLELSEQQE - 240
GQLELSEQQE GQLELSEQQE GQLKHLEHQE GQLEVPEEQM GQLKYLEQQE GQLKHLDQQE - 300
KQPELPEQQM GQLKHLEQQE GQPKHLEQQE GQLEQLEEQE GQLKHLEQQE GQLEHLEHQE - 360
GQLGLPEQQV LQLKQLEKQQ GQPKHLEEEE GQLKHLVQQE GQLKHLVQQE GQLEQQERQV - 420
EHLEQQVGQL KHLEEQEGQL KHLEQQQGQL EVPEQQVGQP KNLEQEEKQL ELPEQQEGQV - 480
KHLEKQEAQL ELPEQQVGQP KHLEQQEKHL EHPEQQDGQL KHLEQQEGQL KDLEQQKGQL - 540
EQPVFAPAPG QVQDIQPALP TKGEVLLPVE HQQQKQEVQW PPKHK

Region 2: 196-225 Region 1: 336-365

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:336 - 365
Length:30
Region sequence:

LEEQEGQLKHLEQQEGQLEHLEHQEGQLGL

Modification type: Engineered
Mutant
PDB:  
Structural/functional type: Relationship to function unknown
Functional classes: Unknown
Functional subclasses: Unknown
Detection methods:
 
References:
  1. Lazo ND, Downing DT. "A mixture of alpha-helical and 3(10)-helical conformations for involucrin in the human epidermal corneocyte envelope provides a scaffold for the attachment of both lipids and proteins." J Biol Chem. 1999; 274(52): 37340-4. PubMed: 10601302
Comments:
Experimental fragment was three repeats of LEQQEGQLEH. This consensus repeat sequence had the following deviations from the native sequence; E248Q and E354K. Note that there are several LEQQEGQLEH repeats in native sequence.


Region 2
Type:Disordered
Name: 
Location:196 - 225
Length:30
Region sequence:

PEQQEGQLELPEQQEGQLELPEQQEGQLEL

Modification type: Engineered
Fragment
Native
PDB:  
Structural/functional type: Relationship to function unknown
Functional classes: Unknown
Functional subclasses: Unknown
Detection methods:
 
References:
  1. Lazo ND, Downing DT. "A mixture of alpha-helical and 3(10)-helical conformations for involucrin in the human epidermal corneocyte envelope provides a scaffold for the attachment of both lipids and proteins." J Biol Chem. 1999; 274(52): 37340-4. PubMed: 10601302
Comments:
The experimental sequence consisted of three repeats of PEQQEGQLEL. Note that there are several PEQQEGQLEL repeats in the native sequence.



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