|Location:||724 - 760|
|Modification type: ||Fragment |
|PDB: || |
|Structural/functional type: ||Function arises via a disorder to order transition |
|Functional classes: ||Molecular recognition effectors |
|Functional subclasses: ||Protein-protein binding |
|Detection methods: |
- Circular dichroism (CD) spectroscopy, far-UV
- Nuclear magnetic resonance (NMR)
- Analytical ultracentrifugation
- Haarmann CS, Green D, Casarotto MG, Laver DR, Dulhunty AF. "The random-coil 'C' fragment of the dihydropyridine receptor II-III loop can activate or inhibit native skeletal ryanodine receptors." Biochem J. 2003; 372(Pt 2): 305-16. PubMed: 12620094
Peptide C is sufficient to activate the ryanodine receptor at physiological concentrations.
Structure determination experiments were conducted on isolated peptide C.