Annotation for this protein is in progress - please check future releases for more complete information


DP00248: Acylamino-acid-releasing enzymeFASTA viewXML view

General information
DisProt:DP00248
Name:Acylamino-acid-releasing enzyme
Synonym(s):APEH_AERPE
AARE
EC 3.4.19.1
Acyl-peptide hydrolase
APH
Acylaminoacyl-peptidase
First appeared in release:Release 3.0 (02/17/2006)
UniProt:Q9YBQ2
UniGene: 
SwissProt: APEH_AERPE
TrEMBL:  
NCBI (GI): 38257797
Source organism:Aeropyrum pernix (Strain K1)
Sequence length:582
Percent disordered:2%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MRIIMPVEFS RIVRDVERLI AVEKYSLQGV VDGDKLLVVG FSEGSVNAYL YDGGETVKLN - 60
REPINSVLDP HYGVGRVILV RDVSKGAEQH ALFKVNTSRP GEEQRLEAVK PMRILSGVDT - 120
GEAVVFTGAT EDRVALYALD GGGLRELARL PGFGFVSDIR GDLIAGLGFF GGGRVSLFTS - 180
NLSSGGLRVF DSGEGSFSSA SISPGMKVTA GLETAREARL VTVDPRDGSV EDLELPSKDF - 240
SSYRPTAITW LGYLPDGRLA VVARREGRSA VFIDGERVEA PQGNHGRVVL WRGKLVTSHT - 300
SLSTPPRIVS LPSGEPLLEG GLPEDLRRSI AGSRLVWVES FDGSRVPTYV LESGRAPTPG - 360
PTVVLVHGGP FAEDSDSWDT FAASLAAAGF HVVMPNYRGS TGYGEEWRLK IIGDPCGGEL - 420
EDVSAAARWA RESGLASELY IMGYSYGGYM TLCALTMKPG LFKAGVAGAS VVDWEEMYEL - 480
SDAAFRNFIE QLTGGSREIM RSRSPINHVD RIKEPLALIH PQNDSRTPLK PLLRLMGELL - 540
ARGKTFEAHI IPDAGHAINT MEDAVKILLP AVFFLATQRE RR

Region 1: 1-7 Region 3: 1-8 Region 2: 582-582

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:1 - 7
Length:7
Region sequence:

MRIIMPV

Modification type:  
PDB: 1VE6:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
  1. X-ray crystallography (291 K; pH: 4.6; DTT (per l) 15 mM; EDTA (per l) 0.2 mM; NaAC (per l) 50 mM; PEG4000 6 %)
References:
  1. Bartlam M, Wang G, Yang H, Gao R, Zhao X, Xie G, Cao S, Feng Y, Rao Z. "Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1." Structure. 2004; 12(8): 1481-8. PubMed: 15296741
Comments:
 



Region 2
Type:Disordered
Name: 
Location:582 - 582
Length:1
Region sequence:

R

Modification type:  
PDB: 1VE6:A, 1VE7:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
  1. X-ray crystallography (291 K; pH: 4.6; DTT (per l) 15 mM; EDTA (per l) 0.2 mM; NaAC (per l) 50 mM; PEG4000 6 %)
References:
  1. Bartlam M, Wang G, Yang H, Gao R, Zhao X, Xie G, Cao S, Feng Y, Rao Z. "Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1." Structure. 2004; 12(8): 1481-8. PubMed: 15296741
Comments:
 



Region 3
Type:Disordered
Name: 
Location:1 - 8
Length:8
Region sequence:

MRIIMPVE

Modification type: Complex
PDB: 1VE7:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
  1. X-ray crystallography (291 K; pH: 4.6; DTT (per l) 15 mM; EDTA (per l) 0.2 mM; NaAC (per l) 50 mM; PEG4000 6 %)
References:
  1. Bartlam M, Wang G, Yang H, Gao R, Zhao X, Xie G, Cao S, Feng Y, Rao Z. "Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1." Structure. 2004; 12(8): 1481-8. PubMed: 15296741
Comments:
This region is disordered when in a complex with p-nitrophenyl phosphate (pNP).


References

  1. Kawarabayasi Y, Hino Y, Horikawa H, Yamazaki S, Haikawa Y, Jin-no K, Takahashi M, Sekine M, Baba S, Ankai A, Kosugi H, Hosoyama A, Fukui S, Nagai Y, Nishijima K, Nakazawa H, Takamiya M, Masuda S, Funahashi T, Tanaka T, Kudoh Y, Yamazaki J, Kushida N, Oguchi A, Kikuchi H, et al. "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." DNA Res. 1999; 6(2): 83-101, 145-52. PubMed: 10382966


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