Annotation for this protein is in progress - please check future releases for more complete information


DP00256: SecurinFASTA viewXML view

General information
DisProt:DP00256
Name:Securin
Synonym(s):SECU_YEAST
First appeared in release:Release 3.0 (02/17/2006)
UniProt:P40316
UniGene: 
SwissProt: SECU_YEAST
TrEMBL:  
NCBI (GI): 730288
Source organism:Saccharomyces cerevisiae (Baker's yeast)
Sequence length:373
Percent disordered:29%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MMPANEDKEN NIVYTGNESS GINFPQTPAH LLKRSHSNIL KPPVRLDQLK RDANSNNGNT - 60
LKYIQGGKEV SPTKRLHTHA QQQGRLPLAA KDNNRSKSFI FPETSNQSKD ADLPQLQNTL - 120
SIRKNDQLRK LSQISRSRSR ANHNDLLSNS RKLQKYGSVL GYNALPKMKS LVLKDLADSG - 180
KNEESSDDDE GNEDSESKLG KKLQSALLKQ DSSDGENELN GGLGLFNEQG GLQQLIKNST - 240
KNEQKTKNDK SDKTDDYDIE IAPQRQEPLP YVPEGYSPFQ QDDIEKLKTF NSPYKLDLED - 300
EDDTPDKVDL LPLEQIDEEG EKDETECITR NQEEGAALPL LSKNFKEVAA VPTMELVYSE - 360
EGLDPEELED LVT

Region 1: 1-110

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:1 - 110
Length:110
Region sequence:

MMPANEDKENNIVYTGNESSGINFPQTPAHLLKRSHSNILKPPVRLDQLKRDANSNNGNT
LKYIQGGKEVSPTKRLHTHAQQQGRLPLAAKDNNRSKSFIFPETSNQSKD

Modification type: Engineered
Fragment
PDB:  
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
  1. Circular dichroism (CD) spectroscopy, near-UV (pH: 7; ND-Pds1 (per ml) 0.05 mg; sodium phosphate 10 mM)

  2. Nuclear magnetic resonance (NMR) (298 K; pH: 7.2; D2O (v/v) 5 %; NaCl 140 mM; NaN3 50 uM; NaPi 12 mM; ND-Pds1 1 mM)
References:
  1. Cox CJ, Dutta K, Petri ET, Hwang WC, Lin Y, Pascal SM, Basavappa R. "The regions of securin and cyclin B proteins recognized by the ubiquitination machinery are natively unfolded." FEBS Lett. 2002; 527(1-3): 303-8. PubMed: 12220679
Comments:
 



References

  1. Yamamoto A, Guacci V, Koshland D. "Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae." J Cell Biol. 1996; 133(1): 85-97. PubMed: 8601616



Comments


The destruction of securin facilitates sister chromatid segregation by releasing the binding partner of securin, separase, which then cleaves the protein complexes that bind together the sister chromatids.


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