Annotation for this protein is in progress - please check future releases for more complete information


DP00261: Sialidase-2FASTA viewXML view

General information
DisProt:DP00261
Name:Sialidase-2
Synonym(s):NEUR2_HUMAN
EC 3.2.1.18
Cytosolic sialidase
N-acetyl-alpha-neuraminidase 2
First appeared in release:Release 3.0 (02/17/2006)
UniProt:Q9Y3R4
UniGene:Hs.532681
SwissProt: NEUR2_HUMAN
TrEMBL:  
NCBI (GI): 229462907
Source organism:Homo sapiens (Human)
Sequence length:380
Percent disordered:5%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MASLPVLQKE SVFQSGAHAY RIPALLYLPG QQSLLAFAEQ RASKKDEHAE LIVLRRGDYD - 60
APTHQVQWQA QEVVAQARLD GHRSMNPCPL YDAQTGTLFL FFIAIPGQVT EQQQLQTRAN - 120
VTRLCQVTST DHGRTWSSPR DLTDAAIGPA YREWSTFAVG PGHCLQLNDR ARSLVVPAYA - 180
YRKLHPIQRP IPSAFCFLSH DHGRTWARGH FVAQDTLECQ VAEVETGEQR VVTLNARSHL - 240
RARVQAQSTN DGLDFQESQL VKKLVEPPPQ GCQGSVISFP SPRSGPGSPA QWLLYTHPTH - 300
SWQRADLGAY LNPRPPAPEA WSEPVLLAKG SCAYSDLQSM GTGPDGSPLF GCLYEANDYE - 360
EIVFLMFTLK QAFPAEYLPQ

Region 1: 42-48 Region 2: 107-118

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:alpha-1 helix
Location:42 - 48
Length:7
Region sequence:

ASKKDEH

Modification type:  
PDB:  
Structural/functional type: Function arises via a disorder to order transition
Functional classes:  
Functional subclasses:  
Detection methods:
  1. X-ray crystallography (298 K; pH: 6.2; NaCl 2.5 M; protein (per ml) 10 mg; sodium/potassium phosphate (buffer ) 100 mM)
References:
  1. Chavas LM, Tringali C, Fusi P, Venerando B, Tettamanti G, Kato R, Monti E, Wakatsuki S. "Crystal structure of the human cytosolic sialidase Neu2. Evidence for the dynamic nature of substrate recognition." J Biol Chem. 2005; 280(1): 469-75. PubMed: 15501818
Comments:
 



Region 2
Type:Disordered
Name:alpha-2 helix
Location:107 - 118
Length:12
Region sequence:

GQVTEQQQLQTR

Modification type:  
PDB:  
Structural/functional type: Function arises via a disorder to order transition
Functional classes:  
Functional subclasses: Substrate/ligand binding
Detection methods:
  1. X-ray crystallography (298 K; pH: 6.2; NaCl 2.5 M; protein (per ml) 10 mg; sodium/potassium phosphate (buffer) 100 mM)
References:
  1. Chavas LM, Tringali C, Fusi P, Venerando B, Tettamanti G, Kato R, Monti E, Wakatsuki S. "Crystal structure of the human cytosolic sialidase Neu2. Evidence for the dynamic nature of substrate recognition." J Biol Chem. 2005; 280(1): 469-75. PubMed: 15501818
Comments:
 


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