Annotation for this protein is in progress - please check future releases for more complete information


DP00269: DE-cadherinFASTA viewXML view

General information
DisProt:DP00269
Name:DE-cadherin
Synonym(s):CADE_DROME
Protein shotgun
First appeared in release:Release 3.0 (02/17/2006)
UniProt:Q24298
UniGene:Dm.4731
SwissProt: CADE_DROME
TrEMBL:  
NCBI (GI): 13124007
Source organism:Drosophila melanogaster (Fruit fly)
Sequence length:1507
Percent disordered:10%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MSTSVQRMSR SYHCINMSAT PQAGHLNPAQ QQTHQQHKRK CRDLGRRLIP ARLLLGVIVA - 60
ISLLSPALAL HSPPDKNFSG DNRKPAFKNC AGYAPKVKEE QPENTYVLTV EAVDPDPDQV - 120
IRYSIVQSPF ERPKFFINPS TGVIFTTHTF DRDEPIHEKF VFVTVQATDN GLPPLDDVCT - 180
FNVTIEDIND NAPAFNKARY DESMSENAQP DAVVMTISAS DFDDGNNSLV EYEILRERDF - 240
QYFKIDKESG IIYLKRPIDK RPGQSYAIIV RAYNVVPDPP QDAQIEVRIR VVESSIKPPS - 300
FVNPIDTPIY LKENLKNFTH PIATLRAVSN MPDKPEVIFE LNTGRTEQTN SKNTFVFNQI - 360
GNEVTISLGK TLDYEAITDY TLTMIVRNTH ELGTEHQIKI QVEDVNDNIP YYTEVKSGTI - 420
LENEPPGTPV MQVRAFDMDG TSANNIVSFE LADNREYFTI DPNTGNITAL TTFDREERDF - 480
YNVKVIASDN SPSSLFDNGE PNRGHQVFRI SIGDKNDHKP HFQQDKYLAE RLLEDANTNT - 540
EVIEVKAEDE DNASQILYSI ESGNVGDAFK IGLKTGKITV NQKLDYETIT EYELKVRAFD - 600
GIYDDYTTVV IKIEDVNDNP PVFKQDYSVT ILEETTYDDC ILTVEAYDPD IKDRNADQHI - 660
VYSIHQNDGN RWTIDNSGCL RLVKTLDRDP PNGHKNWQVL IKANDEDGVG TTVSTVKEVT - 720
VTLKDINDNA PFLINEMPVY WQENRNPGHV VQLQANDYDD TPGAGNFTFG IDSEATPDIK - 780
TKFSMDGDYL HANVQFDREA QKEYFIPIRI SDSGVPRQSA VSILHLVIGD VNDNAMSEGS - 840
SRIFIYNYKG EAPETDIGRV FVDDLDDWDL EDKYFEWKDL PHDQFRLNPS TGMITMLVHT - 900
AEGEYDLSFV VTEDSMFVPR HSVDAYVTVV VRELPEEAVD KSGSIRFINV TKEEFISVPR - 960
DFQSPDALSL KDRLQLSLAK LFNTSVSNVD VFTVLQNENH TLDVRFSAHG SPYYAPEKLN - 1020
GIVAQNQQRL ENELDLQMLM VNIDECLIEK FKCEESCTNE LHKSSVPYMI YSNTTSFVGV - 1080
NAFVQAQCVC EAPLMRRCLN GGSPRYGEND VCDCIDGFTG PHCELVSVAF YGSGYAFYEP - 1140
IAACNNTKIS LEITPQIDQG LIMYLGPLNF NPLLAISDFL ALELDNGYPV LTVDYGSGAI - 1200
RIRHQHIKMV ADRTYQLDII LQRTSIEMTV DNCRLSTCQT LGAPIGPNEF LNVNAPLQLG - 1260
GTPVDLEQLG RQLNWTHVPN QKGFFGCIRN LTINEQTYNL GMPSVFRNID SGCQQSVAVA - 1320
FSFGIDRNFI IAIIVCLALL LIILLAVVVQ KKQKNGWHEK DIDDIRETII NYEDEGGGER - 1380
DTDYDLNVLR TQPFYEEKLY KDPHALQGNM RDPNDIPDIA DFLGDKKENC DRDVGATTVD - 1440
DVRHYAYEGD GNSDGSLSSL ASCTDDGDLN FDYLSNFGPR FRKLADMYGE EPSDTDSNVD - 1500
DDQGWRI

Region 1: 1350-1507

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:cytoplasmic domain
Location:1350 - 1507
Length:158
Region sequence:

QKKQKNGWHEKDIDDIRETIINYEDEGGGERDTDYDLNVLRTQPFYEEKLYKDPHALQGN
MRDPNDIPDIADFLGDKKENCDRDVGATTVDDVRHYAYEGDGNSDGSLSSLASCTDDGDL
NFDYLSNFGPRFRKLADMYGEEPSDTDSNVDDDQGWRI

Modification type: Fragment
PDB:  
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
  1. Fluorescence polarization/anisotropy (beta76 2 mM; beta-catenin 3.5 mM; bovin serum albumin 3 mM; protein (6,3, or 1.5 mM); tryptophan (12 or 14 mM))

  2. Circular dichroism (CD) spectroscopy, near-UV (273 K; pH: 7; phosphate 10 mM)
References:
  1. Huber AH, Stewart DB, Laurents DV, Nelson WJ, Weis WI. "The cadherin cytoplasmic domain is unstructured in the absence of beta-catenin. A possible mechanism for regulating cadherin turnover." J Biol Chem. 2001; 276(15): 12301-12309. PubMed: 11121423

  2. Oda H, Uemura T, Harada Y, Iwai Y, Takeichi M. "A Drosophila homolog of cadherin associated with armadillo and essential for embryonic cell-cell adhesion." Dev Biol. 1994; 165(2): 716-26. PubMed: 7958432
Comments:
 



Comments


It appears that the sequence has been updated since the release of the Oda paper in 1994. The sequence originally had a phenylalanine for residue 974, but this has since been changed to a leucine with further analysis of the genome. The Oda paper is still used as the sequence reference for the UniProt entry listed.


If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us.


Disprot-footer
Contact us