DP00287: Von Hippel-Lindau disease tumor suppressor [Isoform 1]FASTA viewXML view

General information
DisProt:DP00287
Name:Von Hippel-Lindau disease tumor suppressor [Isoform 1]
Synonym(s):VHL_HUMAN
pVHL
Protein G7
VHL30
VHLp24(MPR)
First appeared in release:Release 3.0 (02/17/2006)
UniProt:P40337
UniGene:Hs.517792
SwissProt: VHL_HUMAN
TrEMBL:  
NCBI (GI): 4033778
Source organism:Homo sapiens (Human)
Sequence length:213
Percent disordered:75%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MPRRAENWDE AEVGAEEAGV EEYGPEEDGG EESGAEESGP EESGPEELGA EEEMEAGRPR - 60
PVLRSVNSRE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LPPGTGRRIH SYRGHLWLFR - 120
DAGTHDGLLV NQTELFVPSL NVDGQPIFAN ITLPVYTLKE RCLQVVRSLV KPENYRRLDI - 180
VRSLYEDLED HPNVQKDLER LTQERIAHQR MGD

Region 1: 54-213

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered - Molten Globule
Name: 
Location:54 - 213
Length:160
Region sequence:

MEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYR
GHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPE
NYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD

Modification type: Native
PDB:  
Structural/functional type: Function arises from the molten globule state
Functional classes: Unknown
Functional subclasses: Unknown
Detection methods:
  1. Circular dichroism (CD) spectroscopy, near-UV (298 K; pH: 8; NaCl (buffer) 200 mM; Tris-HCl (buffer) 50 mM)

  2. Dynamic light scattering
References:
  1. Sutovsky H, Gazit E. "The von Hippel-Lindau tumor suppressor protein is a molten globule under native conditions: implications for its physiological activities." J Biol Chem. 2004; 279(17): 17190-6. PubMed: 14963040
Comments:
The physiological role of pVHL is not fully understood. However, it is suggested to play a role in protein degradation in the ubiquitin pathway and to be a regulator of multiple transcription pathways.


References

  1. Iliopoulos O, Kibel A, Gray S, Kaelin WG Jr. "Tumour suppression by the human von Hippel-Lindau gene product." Nat Med. 1995; 1(8): 822-6. PubMed: 7585187



Comments


Sent for AV 8-10-2011 (PubMed: 14963040)


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