Annotation for this protein is in progress - please check future releases for more complete information



DP00294: Methyl-accepting chemotaxis protein IIFASTA viewXML view

General information
DisProt:DP00294
Name:Methyl-accepting chemotaxis protein II
Synonym(s):MCP2_ECOLI
MCP-II
Aspartate chemoreceptor protein
First appeared in release:Release 3.0 (02/17/2006)
UniProt:P07017
UniGene: 
SwissProt: MCP2_ECOLI
TrEMBL:  
NCBI (GI): 2506837
Source organism:Escherichia coli (strain K12)
Sequence length:553
Percent disordered:5%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MINRIRVVTL LVMVLGVFAL LQLISGSLFF SSLHHSQKSF VVSNQLREQQ GELTSTWDLM - 60
LQTRINLSRS AVRMMMDSSN QQSNAKVELL DSARKTLAQA ATHYKKFKSM APLPEMVATS - 120
RNIDEKYKNY YTALTELIDY LDYGNTGAYF AQPTQGMQNA MGEAFAQYAL SSEKLYRDIV - 180
TDNADDYRFA QWQLAVIALV VVLILLVAWY GIRRMLLTPL AKIIAHIREI AGGNLANTLT - 240
IDGRSEMGDL AQSVSHMQRS LTDTVTHVRE GSDAIYAGTR EIAAGNTDLS SRTEQQASAL - 300
EETAASMEQL TATVKQNADN ARQASQLAQS ASDTAQHGGK VVDGVVKTMH EIADSSKKIA - 360
DIISVIDGIA FQTNILALNA AVEAARAGEQ GRGFAVVAGE VRNLASRSAQ AAKEIKALIE - 420
DSVSRVDTGS VLVESAGETM NNIVNAVTRV TDIMGEIASA SDEQSRGIDQ VALAVSEMDR - 480
VTQQNASLVQ ESAAAAAALE EQASRLTQAV SAFRLAASPL TNKPQTPSRP ASEQPPAQPR - 540
LRIAEQDPNW ETF



Functional narrative    

Receptor for the attractant L-aspartate and related amino and dicarboxylic acids. Tar also mediates taxis to the attractant maltose via an interaction with the periplasmic maltose binding protein. Tar mediates taxis away from the repellents cobalt and nickel. Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation, the methyl groups are added by the methyltransferase cheR and removed by the methylesterase cheB.

Region 1: 524-553

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:524 - 553
Length:30
Region sequence:

PQTPSRPASEQPPAQPRLRIAEQDPNWETF

Modification type:  
PDB:  
Structural/functional type: Function arises from the disordered state
Functional classes: Molecular recognition effectors
Functional subclasses: Protein-protein binding
Detection methods:
 
References:
  1. Bray D. "Flexible peptides and cytoplasmic gels." Genome Biol. 2005; 6(3): 106. PubMed: 15774032

Comments:
 



References

  1. Li M, Hazelbauer GL. "Adaptational assistance in clusters of bacterial chemoreceptors." Mol Microbiol. 2005; 56(6): 1617-26. PubMed: 15916610


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