General information | DisProt: | DP00294 | Name: | Methyl-accepting chemotaxis protein II | Synonym(s): | MCP2_ECOLI
MCP-II
Aspartate chemoreceptor protein
| First appeared in release: | Release 3.0 (02/17/2006) | UniProt: | P07017 | UniGene: | | SwissProt: | MCP2_ECOLI | TrEMBL: | | NCBI (GI): | 2506837 | Source organism: | Escherichia coli (strain K12) | Sequence length: | 553 | Percent disordered: | 5% | Homologues: | |
Native sequence |
10 20 30 40 50 60 | | | | | | MINRIRVVTL LVMVLGVFAL LQLISGSLFF SSLHHSQKSF VVSNQLREQQ GELTSTWDLM - 60 LQTRINLSRS AVRMMMDSSN QQSNAKVELL DSARKTLAQA ATHYKKFKSM APLPEMVATS - 120 RNIDEKYKNY YTALTELIDY LDYGNTGAYF AQPTQGMQNA MGEAFAQYAL SSEKLYRDIV - 180 TDNADDYRFA QWQLAVIALV VVLILLVAWY GIRRMLLTPL AKIIAHIREI AGGNLANTLT - 240 IDGRSEMGDL AQSVSHMQRS LTDTVTHVRE GSDAIYAGTR EIAAGNTDLS SRTEQQASAL - 300 EETAASMEQL TATVKQNADN ARQASQLAQS ASDTAQHGGK VVDGVVKTMH EIADSSKKIA - 360 DIISVIDGIA FQTNILALNA AVEAARAGEQ GRGFAVVAGE VRNLASRSAQ AAKEIKALIE - 420 DSVSRVDTGS VLVESAGETM NNIVNAVTRV TDIMGEIASA SDEQSRGIDQ VALAVSEMDR - 480 VTQQNASLVQ ESAAAAAALE EQASRLTQAV SAFRLAASPL TNKPQTPSRP ASEQPPAQPR - 540 LRIAEQDPNW ETF
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Functional narrative |
Receptor for the attractant L-aspartate and related amino and dicarboxylic acids. Tar also mediates taxis to the attractant maltose via an interaction with the periplasmic maltose binding protein. Tar mediates taxis away from the repellents cobalt and nickel.
Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation, the methyl groups are added by the methyltransferase cheR and removed by the methylesterase cheB.
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Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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Region 1 | Type: | Disordered | Name: | | Location: | 524 - 553 | Length: | 30 | Region sequence: |
PQTPSRPASEQPPAQPRLRIAEQDPNWETF | Modification type: | | PDB: | | Structural/functional type: | Function arises from the disordered state | Functional classes: | Molecular recognition effectors
| Functional subclasses: | Protein-protein binding
| Detection methods: | References:
- Bray D. "Flexible peptides and cytoplasmic gels." Genome Biol. 2005; 6(3): 106. PubMed: 15774032
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References |
- Li M, Hazelbauer GL. "Adaptational assistance in clusters of bacterial chemoreceptors." Mol Microbiol. 2005; 56(6): 1617-26. PubMed: 15916610
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