General information | DisProt: | DP00295 | Name: | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase | Synonym(s): | GPMA_MYCTU
Phosphoglyceromutase
PGAM
BPG-dependent PGAM
dPGM
EC=5.4.2.1
| First appeared in release: | Release 3.0 (02/17/2006) | UniProt: | P0A5R6 | UniGene: | | SwissProt: | GPMA_MYCTU | TrEMBL: | | NCBI (GI): | 61225470 | Source organism: | Mycobacterium tuberculosis | Sequence length: | 249 | Percent disordered: | 6% | Homologues: | |
Native sequence |
10 20 30 40 50 60 | | | | | | MANTGSLVLL RHGESDWNAL NLFTGWVDVG LTDKGQAEAV RSGELIAEHD LLPDVLYTSL - 60 LRRAITTAHL ALDSADRLWI PVRRSWRLNE RHYGALQGLD KAETKARYGE EQFMAWRRSY - 120 DTPPPPIERG SQFSQDADPR YADIGGGPLT ECLADVVARF LPYFTDVIVG DLRVGKTVLI - 180 VAHGNSLRAL VKHLDQMSDD EIVGLNIPTG IPLRYDLDSA MRPLVRGGTY LDPEAAAAGA - 240 AAVAGQGRG
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Functional narrative |
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
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Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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Region 1 | Type: | Disordered | Name: | | Location: | 245 - 249 | Length: | 5 | Region sequence: |
GQGRG | Modification type: | Engineered
Monomeric
| PDB: | 1RII:A | Structural/functional type: | Function arises via a disorder to order transition | Functional classes: | Molecular recognition effectors
| Functional subclasses: | Intraprotein interaction
| Detection methods:
- X-ray crystallography (298 K; MgCl2 0.2 M; PEG 3350 20 %)
| References:
- Muller P, Sawaya MR, Pashkov I, Chan S, Nguyen C, Wu Y, Perry LJ, Eisenberg D. "The 1.70 angstroms X-ray crystal structure of Mycobacterium tuberculosis phosphoglycerate mutase." Acta Crystallogr D Biol Crystallogr. 2005; 61(Pt 3): 309-15. PubMed: 15735341
| Comments:This region was disordered in chain A.
This region contained an additional C-terminal His tag that was composed of the following residues: GVPRGAAALEHHHHHH. These residues were also found to be disordered in the experiment.
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Region 2 | Type: | Disordered | Name: | | Location: | 240 - 249 | Length: | 10 | Region sequence: |
AAAVAGQGRG | Modification type: | Engineered
Monomeric
| PDB: | 1RII:B | Structural/functional type: | Function arises via a disorder to order transition | Functional classes: | Molecular recognition effectors
| Functional subclasses: | Intraprotein interaction
| Detection methods:
- X-ray crystallography (298 K; MgCl2 0.2 M; PEG 3350 20 %)
| References:
- Muller P, Sawaya MR, Pashkov I, Chan S, Nguyen C, Wu Y, Perry LJ, Eisenberg D. "The 1.70 angstroms X-ray crystal structure of Mycobacterium tuberculosis phosphoglycerate mutase." Acta Crystallogr D Biol Crystallogr. 2005; 61(Pt 3): 309-15. PubMed: 15735341
| Comments:This region was disordered in chain B.
This region contained an additional C-terminal His tag that was composed of the following residues: GVPRGAAALEHHHHHH. These residues were also found to be disordered in the experiment.
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Region 3 | Type: | Disordered | Name: | | Location: | 239 - 249 | Length: | 11 | Region sequence: |
GAAAVAGQGRG | Modification type: | Engineered
Monomeric
| PDB: | 1RII:C | Structural/functional type: | Function arises via a disorder to order transition | Functional classes: | Molecular recognition effectors
| Functional subclasses: | Intraprotein interaction
| Detection methods:
- X-ray crystallography (298 K; MgCl2 0.2 M; PEG 3350 20 %)
| References:
- Muller P, Sawaya MR, Pashkov I, Chan S, Nguyen C, Wu Y, Perry LJ, Eisenberg D. "The 1.70 angstroms X-ray crystal structure of Mycobacterium tuberculosis phosphoglycerate mutase." Acta Crystallogr D Biol Crystallogr. 2005; 61(Pt 3): 309-15. PubMed: 15735341
| Comments:This region was disordered in chain C.
This region contained an additional C-terminal His tag that was composed of the following residues: GVPRGAAALEHHHHHH. These residues were also found to be disordered in the experiment.
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Region 4 | Type: | Disordered | Name: | | Location: | 234 - 249 | Length: | 16 | Region sequence: |
EAAAAGAAAVAGQGRG | Modification type: | Engineered
Monomeric
| PDB: | 1RII:D | Structural/functional type: | Function arises via a disorder to order transition | Functional classes: | Molecular recognition effectors
| Functional subclasses: | Intraprotein interaction
| Detection methods:
- X-ray crystallography (298 K; MgCl2 0.2 M; PEG 3350 20 %)
| References:
- Muller P, Sawaya MR, Pashkov I, Chan S, Nguyen C, Wu Y, Perry LJ, Eisenberg D. "The 1.70 angstroms X-ray crystal structure of Mycobacterium tuberculosis phosphoglycerate mutase." Acta Crystallogr D Biol Crystallogr. 2005; 61(Pt 3): 309-15. PubMed: 15735341
| Comments:This region was disordered in chain D.
This region contained an additional C-terminal His tag that was composed of the following residues: GVPRGAAALEHHHHHH. These residues were also found to be disordered in the experiment.
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