Annotation for this protein is in progress - please check future releases for more complete information



DP00295: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseFASTA viewXML view

General information
DisProt:DP00295
Name:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
Synonym(s):GPMA_MYCTU
Phosphoglyceromutase
PGAM
BPG-dependent PGAM
dPGM
EC=5.4.2.1
First appeared in release:Release 3.0 (02/17/2006)
UniProt:P0A5R6
UniGene: 
SwissProt: GPMA_MYCTU
TrEMBL:  
NCBI (GI): 61225470
Source organism:Mycobacterium tuberculosis
Sequence length:249
Percent disordered:6%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MANTGSLVLL RHGESDWNAL NLFTGWVDVG LTDKGQAEAV RSGELIAEHD LLPDVLYTSL - 60
LRRAITTAHL ALDSADRLWI PVRRSWRLNE RHYGALQGLD KAETKARYGE EQFMAWRRSY - 120
DTPPPPIERG SQFSQDADPR YADIGGGPLT ECLADVVARF LPYFTDVIVG DLRVGKTVLI - 180
VAHGNSLRAL VKHLDQMSDD EIVGLNIPTG IPLRYDLDSA MRPLVRGGTY LDPEAAAAGA - 240
AAVAGQGRG



Functional narrative    

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

Region 4: 234-249 Region 3: 239-249 Region 2: 240-249 Region 1: 245-249

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:245 - 249
Length:5
Region sequence:

GQGRG

Modification type: Engineered
Monomeric
PDB: 1RII:A
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Molecular recognition effectors
Functional subclasses: Intraprotein interaction
Detection methods:
  1. X-ray crystallography (298 K; MgCl2 0.2 M; PEG 3350 20 %)

References:
  1. Muller P, Sawaya MR, Pashkov I, Chan S, Nguyen C, Wu Y, Perry LJ, Eisenberg D. "The 1.70 angstroms X-ray crystal structure of Mycobacterium tuberculosis phosphoglycerate mutase." Acta Crystallogr D Biol Crystallogr. 2005; 61(Pt 3): 309-15. PubMed: 15735341

Comments:
This region was disordered in chain A.


This region contained an additional C-terminal His tag that was composed of the following residues: GVPRGAAALEHHHHHH. These residues were also found to be disordered in the experiment.




Region 2
Type:Disordered
Name: 
Location:240 - 249
Length:10
Region sequence:

AAAVAGQGRG

Modification type: Engineered
Monomeric
PDB: 1RII:B
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Molecular recognition effectors
Functional subclasses: Intraprotein interaction
Detection methods:
  1. X-ray crystallography (298 K; MgCl2 0.2 M; PEG 3350 20 %)

References:
  1. Muller P, Sawaya MR, Pashkov I, Chan S, Nguyen C, Wu Y, Perry LJ, Eisenberg D. "The 1.70 angstroms X-ray crystal structure of Mycobacterium tuberculosis phosphoglycerate mutase." Acta Crystallogr D Biol Crystallogr. 2005; 61(Pt 3): 309-15. PubMed: 15735341

Comments:
This region was disordered in chain B.


This region contained an additional C-terminal His tag that was composed of the following residues: GVPRGAAALEHHHHHH. These residues were also found to be disordered in the experiment.




Region 3
Type:Disordered
Name: 
Location:239 - 249
Length:11
Region sequence:

GAAAVAGQGRG

Modification type: Engineered
Monomeric
PDB: 1RII:C
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Molecular recognition effectors
Functional subclasses: Intraprotein interaction
Detection methods:
  1. X-ray crystallography (298 K; MgCl2 0.2 M; PEG 3350 20 %)

References:
  1. Muller P, Sawaya MR, Pashkov I, Chan S, Nguyen C, Wu Y, Perry LJ, Eisenberg D. "The 1.70 angstroms X-ray crystal structure of Mycobacterium tuberculosis phosphoglycerate mutase." Acta Crystallogr D Biol Crystallogr. 2005; 61(Pt 3): 309-15. PubMed: 15735341

Comments:
This region was disordered in chain C.


This region contained an additional C-terminal His tag that was composed of the following residues: GVPRGAAALEHHHHHH. These residues were also found to be disordered in the experiment.




Region 4
Type:Disordered
Name: 
Location:234 - 249
Length:16
Region sequence:

EAAAAGAAAVAGQGRG

Modification type: Engineered
Monomeric
PDB: 1RII:D
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Molecular recognition effectors
Functional subclasses: Intraprotein interaction
Detection methods:
  1. X-ray crystallography (298 K; MgCl2 0.2 M; PEG 3350 20 %)

References:
  1. Muller P, Sawaya MR, Pashkov I, Chan S, Nguyen C, Wu Y, Perry LJ, Eisenberg D. "The 1.70 angstroms X-ray crystal structure of Mycobacterium tuberculosis phosphoglycerate mutase." Acta Crystallogr D Biol Crystallogr. 2005; 61(Pt 3): 309-15. PubMed: 15735341

Comments:
This region was disordered in chain D.


This region contained an additional C-terminal His tag that was composed of the following residues: GVPRGAAALEHHHHHH. These residues were also found to be disordered in the experiment.



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