Annotation for this protein is in progress - please check future releases for more complete information


DP00297: Apoptosis regulator Bcl-2FASTA viewXML view

General information
DisProt:DP00297
Name:Apoptosis regulator Bcl-2
Synonym(s):BCL2_HUMAN
First appeared in release:Release 3.0 (02/17/2006)
UniProt:P10415
UniGene:Hs.150749
SwissProt: BCL2_HUMAN
TrEMBL:  
NCBI (GI): 231632
Source organism:Homo sapiens (Human)
Sequence length:239
Percent disordered:26%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MAHAGRTGYD NREIVMKYIH YKLSQRGYEW DAGDVGAAPP GAAPAPGIFS SQPGHTPHPA - 60
ASRDPVARTS PLQTPAAPGA AAGPALSPVP PVVHLTLRQA GDDFSRRYRR DFAEMSSQLH - 120
LTPFTARGRF ATVVEELFRD GVNWGRIVAF FEFGGVMCVE SVNREMSPLV DNIALWMTEY - 180
LNRHLHTWIQ DNGGWDAFVE LYGPSMRPLF DFSWLSLKTL LSLALVGACI TLGAYLGHK

Region 1: 31-92

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:flexible loop
Location:31 - 92
Length:62
Region sequence:

DAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVP
PV

Modification type:  
PDB:  
Structural/functional type: Function arises from the disordered state
Functional classes: Molecular assembly
Functional subclasses: Protein-protein binding
Detection methods:
  1. X-ray crystallography

  2. Nuclear magnetic resonance (NMR)
References:
  1. Kang CB, Tai J, Chia J, Yoon HS. "The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38)." FEBS Lett. 2005; 579(6): 1469-76. PubMed: 15733859
Comments:
 



References

  1. Muchmore SW, Sattler M, Liang H, Meadows RP, Harlan JE, Yoon HS, Nettesheim D, Chang BS, Thompson CB, Wong SL, Ng SL, Fesik SW. "X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death." Nature. 1996; 381(6580): 335-41. PubMed: 8692274


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