| General information | | DisProt: | DP00300 | | Name: | Methyl-accepting chemotaxis protein I | | Synonym(s): | MCP1_ECOLI
MCP-I
Serine chemoreceptor protein
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | P02942 | | UniGene: | | | SwissProt: | MCP1_ECOLI | | TrEMBL: | | | NCBI (GI): | 400233 | | Source organism: | Escherichia coli (strain K12) | | Sequence length: | 551 | | Percent disordered: | 6% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MLKRIKIVTS LLLVLAVFGL LQLTSGGLFF NALKNDKENF TVLQTIRQQQ STLNGSWVAL - 60
LQTRNTLNRA GIRYMMDQNN IGSGSTVAEL MESASISLKQ AEKNWADYEA LPRDPRQSTA - 120
AAAEIKRNYD IYHNALAELI QLLGAGKINE FFDQPTQGYQ DGFEKQYVAY MEQNDRLHDI - 180
AVSDNNASYS QAMWILVGVM IVVLAVIFAV WFGIKASLVA PMNRLIDSIR HIAGGDLVKP - 240
IEVDGSNEMG QLAESLRHMQ GELMRTVGDV RNGANAIYSG ASEIATGNND LSSRTEQQAA - 300
SLEETAASME QLTATVKQNA ENARQASHLA LSASETAQRG GKVVDNVVQT MRDISTSSQK - 360
IADIISVIDG IAFQTNILAL NAAVEAARAG EQGRGFAVVA GEVRNLAQRS AQAAREIKSL - 420
IEDSVGKVDV GSTLVESAGE TMAEIVSAVT RVTDIMGEIA SASDEQSRGI DQVGLAVAEM - 480
DRVTQQNAAL VEESAAAAAA LEEQASRLTE AVAVFRIQQQ QRETSAVVKT VTPAAPRKMA - 540
VADSEENWET F
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| Functional narrative |
Receptor for the attractant L-serine and related amino acids. Is also responsible for chemotaxis away from a wide range of repellents, including leucine, indole, and weak acids.
Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation, the methyl groups are added by the methyltransferase cheR and removed by the methylesterase cheB.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 521 - 551 | | Length: | 31 | | Region sequence: |
QRETSAVVKTVTPAAPRKMAVADSEENWETF | | Modification type: | | | PDB: | | | Structural/functional type: | Function arises from the disordered state
| | Functional classes: | Molecular recognition effectors
| | Functional subclasses: | Protein-protein binding
| Detection methods:
| References:
- Bray D. "Flexible peptides and cytoplasmic gels." Genome Biol. 2005; 6(3): 106. PubMed: 15774032
| Comments:
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| References |
- Li M, Hazelbauer GL. "Adaptational assistance in clusters of bacterial chemoreceptors." Mol Microbiol. 2005; 56(6): 1617-26. PubMed: 15916610
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