| General information | | DisProt: | DP00311 | | Name: | Immunoglobulin alpha Fc receptor [Isoform A.1] | | Synonym(s): | FCAR_HUMAN
IgA Fc receptor
Antigen CD89
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | P24071-1 | | UniGene: | Hs.659872 | | SwissProt: | FCAR_HUMAN | | TrEMBL: | | | NCBI (GI): | 119860 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 287 | | Percent disordered: | 6% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
| | | | | |
MDPKQTTLLC LVLCLGQRIQ AQEGDFPMPF ISAKSSPVIP LDGSVKIQCQ AIREAYLTQL - 60
MIIKNSTYRE IGRRLKFWNE TDPEFVIDHM DANKAGRYQC QYRIGHYRFR YSDTLELVVT - 120
GLYGKPFLSA DRGLVLMPGE NISLTCSSAH IPFDRFSLAK EGELSLPQHQ SGEHPANFSL - 180
GPVDLNVSGI YRCYGWYNRS PYLWSFPSNA LELVVTDSIH QDYTTQNLIR MAVAGLVLVA - 240
LLAILVENWH SHTALNKEAS ADVAEPSWSQ QMCQPGLTFA RTPSVCK
|
| Functional narrative |
Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.
|
| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
|
| Region 1 | | Type: | Disordered | | Name: | | | Location: | 21 - 21 | | Length: | 1 | | Region sequence: |
A | | Modification type: | | | PDB: | 1UCT:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Ding Y, Xu G, Yang M, Yao M, Gao GF, Wang L, Zhang W, Rao Z. "Crystal structure of the ectodomain of human FcalphaRI." J Biol Chem. 2003; 278(30): 27966-70. PubMed: 12783876
| Comments:
|
| Region 2 | | Type: | Disordered | | Name: | | | Location: | 77 - 80 | | Length: | 4 | | Region sequence: |
FWNE | | Modification type: | | | PDB: | 1UCT:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Ding Y, Xu G, Yang M, Yao M, Gao GF, Wang L, Zhang W, Rao Z. "Crystal structure of the ectodomain of human FcalphaRI." J Biol Chem. 2003; 278(30): 27966-70. PubMed: 12783876
| Comments:
|
| Region 3 | | Type: | Disordered | | Name: | | | Location: | 217 - 229 | | Length: | 13 | | Region sequence: |
DSIHQDYTTQNLI | | Modification type: | | | PDB: | 1UCT:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Ding Y, Xu G, Yang M, Yao M, Gao GF, Wang L, Zhang W, Rao Z. "Crystal structure of the ectodomain of human FcalphaRI." J Biol Chem. 2003; 278(30): 27966-70. PubMed: 12783876
| Comments:
|
| Comments |
This disordered protein entry is based solely on missing electron density in the Protein Data Bank.
|
| If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us. |
Disprot-footer
|
