| General information | | DisProt: | DP00313 | | Name: | Interferon-induced guanylate-binding protein 1 | | Synonym(s): | GBP1_HUMAN
Guanine nucleotide-binding protein 1
GTP-binding protein 1
GBP-1
HuGBP-1
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | P32455 | | UniGene: | Hs.62661 | | SwissProt: | GBP1_HUMAN | | TrEMBL: | | | NCBI (GI): | 417031 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 592 | | Percent disordered: | 9% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MASEIHMTGP MCLIENTNGR LMANPEALKI LSAITQPMVV VAIVGLYRTG KSYLMNKLAG - 60
KKKGFSLGST VQSHTKGIWM WCVPHPKKPG HILVLLDTEG LGDVEKGDNQ NDSWIFALAV - 120
LLSSTFVYNS IGTINQQAMD QLYYVTELTH RIRSKSSPDE NENEVEDSAD FVSFFPDFVW - 180
TLRDFSLDLE ADGQPLTPDE YLTYSLKLKK GTSQKDETFN LPRLCIRKFF PKKKCFVFDR - 240
PVHRRKLAQL EKLQDEELDP EFVQQVADFC SYIFSNSKTK TLSGGIQVNG PRLESLVLTY - 300
VNAISSGDLP CMENAVLALA QIENSAAVQK AIAHYEQQMG QKVQLPTESL QELLDLHRDS - 360
EREAIEVFIR SSFKDVDHLF QKELAAQLEK KRDDFCKQNQ EASSDRCSGL LQVIFSPLEE - 420
EVKAGIYSKP GGYRLFVQKL QDLKKKYYEE PRKGIQAEEI LQTYLKSKES MTDAILQTDQ - 480
TLTEKEKEIE VERVKAESAQ ASAKMLQEMQ RKNEQMMEQK ERSYQEHLKQ LTEKMENDRV - 540
QLLKEQERTL ALKLQEQEQL LKEGFQKESR IMKNEIQDLQ TKMRRRKACT IS
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| Functional narrative |
Binds GTP, GDP and GMP.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 1 - 5 | | Length: | 5 | | Region sequence: |
MASEI | | Modification type: | | | PDB: | 1DG3:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Prakash B, Praefcke GJ, Renault L, Wittinghofer A, Herrmann C. "Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins." Nature. 2000; 403(6769): 567-71. PubMed: 10676968
| Comments:
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| Region 2 | | Type: | Disordered | | Name: | | | Location: | 63 - 73 | | Length: | 11 | | Region sequence: |
KGFSLGSTVQS | | Modification type: | | | PDB: | 1DG3:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Prakash B, Praefcke GJ, Renault L, Wittinghofer A, Herrmann C. "Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins." Nature. 2000; 403(6769): 567-71. PubMed: 10676968
| Comments:
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| Region 3 | | Type: | Disordered | | Name: | | | Location: | 157 - 166 | | Length: | 10 | | Region sequence: |
SPDENENEVE | | Modification type: | | | PDB: | 1DG3:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Prakash B, Praefcke GJ, Renault L, Wittinghofer A, Herrmann C. "Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins." Nature. 2000; 403(6769): 567-71. PubMed: 10676968
| Comments:
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| Region 4 | | Type: | Disordered | | Name: | | | Location: | 190 - 193 | | Length: | 4 | | Region sequence: |
EADG | | Modification type: | | | PDB: | 1DG3:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Prakash B, Praefcke GJ, Renault L, Wittinghofer A, Herrmann C. "Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins." Nature. 2000; 403(6769): 567-71. PubMed: 10676968
| Comments:
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| Region 5 | | Type: | Disordered | | Name: | | | Location: | 244 - 256 | | Length: | 13 | | Region sequence: |
RRKLAQLEKLQDE | | Modification type: | | | PDB: | 1DG3:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Prakash B, Praefcke GJ, Renault L, Wittinghofer A, Herrmann C. "Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins." Nature. 2000; 403(6769): 567-71. PubMed: 10676968
| Comments:
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| Region 6 | | Type: | Disordered | | Name: | | | Location: | 584 - 592 | | Length: | 9 | | Region sequence: |
RRRKACTIS | | Modification type: | | | PDB: | 1DG3:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Prakash B, Praefcke GJ, Renault L, Wittinghofer A, Herrmann C. "Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins." Nature. 2000; 403(6769): 567-71. PubMed: 10676968
| Comments:
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| Comments |
This disordered protein entry is based solely on missing electron density in the Protein Data Bank.
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