| General information | | DisProt: | DP00315 | | Name: | Serine protease HTRA2, mitochondrial [Isoform 1 (13B)] | | Synonym(s): | HTRA2_HUMAN
High temperature requirement protein A2
HtrA2
Omi stress-regulated endoprotease
Serine proteinase OMI
Serine protease 25
EC=3.4.21.108
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | O43464-1 | | UniGene: | Hs.469045 | | SwissProt: | HTRA2_HUMAN | | TrEMBL: | | | NCBI (GI): | 17376879 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 458 | | Percent disordered: | 6% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MAAPRAGRGA GWSLRAWRAL GGIRWGRRPR LTPDLRALLT SGTSDPRARV TYGTPSLWAR - 60
LSVGVTEPRA CLTSGTPGPR AQLTAVTPDT RTREASENSG TRSRAWLAVA LGAGGAVLLL - 120
LWGGGRGPPA VLAAVPSPPP ASPRSQYNFI ADVVEKTAPA VVYIEILDRH PFLGREVPIS - 180
NGSGFVVAAD GLIVTNAHVV ADRRRVRVRL LSGDTYEAVV TAVDPVADIA TLRIQTKEPL - 240
PTLPLGRSAD VRQGEFVVAM GSPFALQNTI TSGIVSSAQR PARDLGLPQT NVEYIQTDAA - 300
IDFGNSGGPL VNLDGEVIGV NTMKVTAGIS FAIPSDRLRE FLHRGEKKNS SSGISGSQRR - 360
YIGVMMLTLS PSILAELQLR EPSFPDVQHG VLIHKVILGS PAHRAGLRPG DVILAIGEQM - 420
VQNAEDVYEA VRTQSQLAVQ IRRGRETLTL YVTPEVTE
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| Functional narrative |
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 134 - 138 | | Length: | 5 | | Region sequence: |
AVPSP | | Modification type: | | | PDB: | 1LCY:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Li W, Srinivasula SM, Chai J, Li P, Wu JW, Zhang Z, Alnemri ES, Shi Y. "Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi." Nat Struct Biol. 2002; 9(6): 436-41. PubMed: 11967569
| Comments:
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| Region 2 | | Type: | Disordered | | Name: | | | Location: | 282 - 290 | | Length: | 9 | | Region sequence: |
ARDLGLPQT | | Modification type: | | | PDB: | 1LCY:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Li W, Srinivasula SM, Chai J, Li P, Wu JW, Zhang Z, Alnemri ES, Shi Y. "Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi." Nat Struct Biol. 2002; 9(6): 436-41. PubMed: 11967569
| Comments:
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| Region 3 | | Type: | Disordered | | Name: | | | Location: | 344 - 358 | | Length: | 15 | | Region sequence: |
RGEKKNSSSGISGSQ | | Modification type: | | | PDB: | 1LCY:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Li W, Srinivasula SM, Chai J, Li P, Wu JW, Zhang Z, Alnemri ES, Shi Y. "Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi." Nat Struct Biol. 2002; 9(6): 436-41. PubMed: 11967569
| Comments:
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| Comments |
This disordered protein entry is based solely on missing electron density in the Protein Data Bank.
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