| General information | | DisProt: | DP00318 | | Name: | Nuclear pore complex protein Nup133 | | Synonym(s): | NU133_HUMAN
Nucleoporin Nup133
133 kDa nucleoporin
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | Q8WUM0 | | UniGene: | Hs.12457 | | SwissProt: | NU133_HUMAN | | TrEMBL: | | | NCBI (GI): | 143811430 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 1156 | | Percent disordered: | 6% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MFPAAPSPRT PGTGSRRGPL AGLGPGSTPR TASRKGLPLG SAVSSPVLFS PVGRRSSLSS - 60
RGTPTRMFPH HSITESVNYD VKTFGSSLPV KVMEALTLAE VDDQLTINID EGGWACLVCK - 120
EKLIIWKIAL SPITKLSVCK ELQLPPSDFH WSADLVALSY SSPSGEAHST QAVAVMVATR - 180
EGSIRYWPSL AGEDTYTEAF VDSGGDKTYS FLTAVQGGSF ILSSSGSQLI RLIPESSGKI - 240
HQHILPQGQG MLSGIGRKVS SLFGILSPSS DLTLSSVLWD RERSSFYSLT SSNISKWELD - 300
DSSEKHAYSW DINRALKENI TDAIWGSESN YEAIKEGVNI RYLDFKQNCD GLVILAAAWH - 360
SADNPCLIYY SLITIEDNGC QMSDAVTVEV TQYNPPFQSE DLILCQLTVP NFSNQTAYLY - 420
NESAVYVCST GTGKFSLPQE KIVFNAQGDS VLGAGACGGV PIIFSRNSGL VSITSRENVS - 480
ILAEDLEGSL ASSVAGPNSE SMIFETTTKN ETIAQEDKIK LLKAAFLQYC RKDLGHAQMV - 540
VDELFSSHSD LDSDSELDRA VTQISVDLMD DYPASDPRWA ESVPEEAPGF SNTSLIILHQ - 600
LEDKMKAHSF LMDFIHQVGL FGRLGSFPVR GTPMATRLLL CEHAEKLSAA IVLKNHHSRL - 660
SDLVNTAILI ALNKREYEIP SNLTPADVFF REVSQVDTIC ECLLEHEEQV LRDAPMDSIE - 720
WAEVVINVNN ILKDMLQAAS HYRQNRNSLY RREESLEKEP EYVPWTATSG PGGIRTVIIR - 780
QHEIVLKVAY PQADSNLRNI VTEQLVALID CFLDGYVSQL KSVDKSSNRE RYDNLEMEYL - 840
QKRSDLLSPL LSLGQYLWAA SLAEKYCDFD ILVQMCEQTD NQSRLQRYMT QFADQNFSDF - 900
LFRWYLEKGK RGKLLSQPIS QHGQLANFLQ AHEHLSWLHE INSQELEKAH ATLLGLANME - 960
TRYFAKKKTL LGLSKLAALA SDFSEDMLQE KIEEMAEQER FLLHQETLPE QLLAEKQLNL - 1020
SAMPVLTAPQ LIGLYICEEN RRANEYDFKK ALDLLEYIDE EEDININDLK LEILCKALQR - 1080
DNWSSSDGKD DPIEVSKDSI FVKILQKLLK DGIQLSEYLP EVKDLLQADQ LGSLKSNPYF - 1140
EFVLKANYEY YVQGQI
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| Functional narrative |
Involved in poly(A)+ RNA transport.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 67 - 74 | | Length: | 8 | | Region sequence: |
MFPHHSIT | | Modification type: | | | PDB: | 1XKS:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Berke IC, Boehmer T, Blobel G, Schwartz TU. "Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex." J Cell Biol. 2004; 167(4): 591-7. PubMed: 15557116
| Comments:
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| Region 2 | | Type: | Disordered | | Name: | | | Location: | 163 - 169 | | Length: | 7 | | Region sequence: |
PSGEAHS | | Modification type: | | | PDB: | 1XKS:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Berke IC, Boehmer T, Blobel G, Schwartz TU. "Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex." J Cell Biol. 2004; 167(4): 591-7. PubMed: 15557116
| Comments:
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| Region 3 | | Type: | Disordered | | Name: | | | Location: | 202 - 205 | | Length: | 4 | | Region sequence: |
DSGG | | Modification type: | | | PDB: | 1XKS:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Berke IC, Boehmer T, Blobel G, Schwartz TU. "Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex." J Cell Biol. 2004; 167(4): 591-7. PubMed: 15557116
| Comments:
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| Region 4 | | Type: | Disordered | | Name: | | | Location: | 252 - 269 | | Length: | 18 | | Region sequence: |
LSGIGRKVSSLFGILSPS | | Modification type: | | | PDB: | 1XKS:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Berke IC, Boehmer T, Blobel G, Schwartz TU. "Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex." J Cell Biol. 2004; 167(4): 591-7. PubMed: 15557116
| Comments:
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| Region 5 | | Type: | Disordered | | Name: | | | Location: | 478 - 514 | | Length: | 37 | | Region sequence: |
NVSILAEDLEGSLASSVAGPNSESMIFETTTKNETIA | | Modification type: | | | PDB: | 1XKS:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Berke IC, Boehmer T, Blobel G, Schwartz TU. "Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex." J Cell Biol. 2004; 167(4): 591-7. PubMed: 15557116
| Comments:
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| Comments |
This disordered protein entry is based solely on missing electron density in the Protein Data Bank.
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