| General information | | DisProt: | DP00323 | | Name: | Nuclear receptor subfamily 1 group I member 2 [Isoform 1A (1)(PRR1-A)] | | Synonym(s): | NR1I2_HUMAN
Orphan nuclear receptor PXR
Pregnane X receptor
Orphan nuclear receptor PAR1
Steroid and xenobiotic receptor
SXR
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | O75469-1 | | UniGene: | Hs.7303 | | SwissProt: | NR1I2_HUMAN | | TrEMBL: | | | NCBI (GI): | 6093860 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 434 | | Percent disordered: | 8% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
| | | | | |
MEVRPKESWN HADFVHCEDT ESVPGKPSVN ADEEVGGPQI CRVCGDKATG YHFNVMTCEG - 60
CKGFFRRAMK RNARLRCPFR KGACEITRKT RRQCQACRLR KCLESGMKKE MIMSDEAVEE - 120
RRALIKRKKS ERTGTQPLGV QGLTEEQRMM IRELMDAQMK TFDTTFSHFK NFRLPGVLSS - 180
GCELPESLQA PSREEAAKWS QVRKDLCSLK VSLQLRGEDG SVWNYKPPAD SGGKEIFSLL - 240
PHMADMSTYM FKGIISFAKV ISYFRDLPIE DQISLLKGAA FELCQLRFNT VFNAETGTWE - 300
CGRLSYCLED TAGGFQQLLL EPMLKFHYML KKLQLHEEEY VLMQAISLFS PDRPGVLQHR - 360
VVDQLQEQFA ITLKSYIECN RPQPAHRFLF LKIMAMLTEL RSINAQHTQR LLRIQDIHPF - 420
ATPLMQELFG ITGS
|
| Functional narrative |
Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.
|
| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
|
| Region 1 | | Type: | Disordered | | Name: | | | Location: | 130 - 141 | | Length: | 12 | | Region sequence: |
SERTGTQPLGVQ | | Modification type: | | | PDB: | 1ILG:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Watkins RE, Wisely GB, Moore LB, Collins JL, Lambert MH, Williams SP, Willson TM, Kliewer SA, Redinbo MR. "The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity." Science. 2001; 292(5525): 2329-33. PubMed: 11408620
| Comments:There is an additional 11 amino acids in the disordered region based upon the PDB sequence. The sequence is as follows: MKKGHHHHHHG. It is located from residue 119 to 129.
|
| Region 2 | | Type: | Disordered | | Name: | | | Location: | 178 - 197 | | Length: | 20 | | Region sequence: |
LSSGCELPESLQAPSREEAA | | Modification type: | | | PDB: | 1ILG:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Watkins RE, Wisely GB, Moore LB, Collins JL, Lambert MH, Williams SP, Willson TM, Kliewer SA, Redinbo MR. "The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity." Science. 2001; 292(5525): 2329-33. PubMed: 11408620
| Comments:
|
| Region 3 | | Type: | Disordered | | Name: | | | Location: | 432 - 434 | | Length: | 3 | | Region sequence: |
TGS | | Modification type: | | | PDB: | 1ILG:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Watkins RE, Wisely GB, Moore LB, Collins JL, Lambert MH, Williams SP, Willson TM, Kliewer SA, Redinbo MR. "The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity." Science. 2001; 292(5525): 2329-33. PubMed: 11408620
| Comments:
|
| Comments |
This disordered protein entry is based solely on missing electron density in the Protein Data Bank.
|
| If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us. |
Disprot-footer
|
