Annotation for this protein is in progress - please check future releases for more complete information



DP00340: Cellular retinoic acid-binding protein 1FASTA viewXML view

General information
DisProt:DP00340
Name:Cellular retinoic acid-binding protein 1
Synonym(s):RABP1_MOUSE
Cellular retinoic acid-binding protein I
CRABP-I
First appeared in release:Release 3.0 (02/17/2006)
UniProt:P62965
UniGene:Mm.34797
SwissProt: RABP1_MOUSE
TrEMBL:  
NCBI (GI): 51702797
Source organism:Mus musculus (Mouse)
Sequence length:137
Percent disordered:23%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MPNFAGTWKM RSSENFDELL KALGVNAMLR KVAVAAASKP HVEIRQDGDQ FYIKTSTTVR - 60
TTEINFKVGE GFEEETVDGR KCRSLPTWEN ENKIHCTQTL LEGDGPKTYW TRELANDELI - 120
LTFGADDVVC TRIYVRE



Functional narrative    

Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.

Region 1: 27-36 Region 2: 60-67 Region 3: 72-76 Region 4: 118-125

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:Alpha 2
Location:27 - 36
Length:10
Region sequence:

AMLRKVAVAA

Modification type: Fragment
PDB:  
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Molecular assembly
Functional subclasses: Protein-protein binding
Detection methods:
  1. Hydrogen-deuterium exchange

References:
  1. Xiao H, Kaltashov IA. "Transient structural disorder as a facilitator of protein-ligand binding: native h/d exchange-mass spectrometry study of cellular retinoic acid binding protein I." J Am Soc Mass Spectrom. 2005; 16(6): 869-79. PubMed: 15907702

Comments:
 



Region 2
Type:Disordered
Name:Beta 4
Location:60 - 67
Length:8
Region sequence:

RTTEINFK

Modification type: Fragment
PDB:  
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Molecular assembly
Functional subclasses: Protein-protein binding
Detection methods:
  1. Hydrogen-deuterium exchange

References:
  1. Xiao H, Kaltashov IA. "Transient structural disorder as a facilitator of protein-ligand binding: native h/d exchange-mass spectrometry study of cellular retinoic acid binding protein I." J Am Soc Mass Spectrom. 2005; 16(6): 869-79. PubMed: 15907702

Comments:
 



Region 3
Type:Disordered
Name:Beta 5
Location:72 - 76
Length:5
Region sequence:

FEEET

Modification type: Fragment
PDB:  
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Molecular assembly
Functional subclasses: Protein-protein binding
Detection methods:
  1. Hydrogen-deuterium exchange

References:
  1. Xiao H, Kaltashov IA. "Transient structural disorder as a facilitator of protein-ligand binding: native h/d exchange-mass spectrometry study of cellular retinoic acid binding protein I." J Am Soc Mass Spectrom. 2005; 16(6): 869-79. PubMed: 15907702

Comments:
 



Region 4
Type:Disordered
Name:Beta 9
Location:118 - 125
Length:8
Region sequence:

ELILTFGA

Modification type: Fragment
PDB:  
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Molecular assembly
Functional subclasses: Protein-protein binding
Detection methods:
  1. Hydrogen-deuterium exchange

References:
  1. Xiao H, Kaltashov IA. "Transient structural disorder as a facilitator of protein-ligand binding: native h/d exchange-mass spectrometry study of cellular retinoic acid binding protein I." J Am Soc Mass Spectrom. 2005; 16(6): 869-79. PubMed: 15907702

Comments:
 


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