| General information | | DisProt: | DP00340 | | Name: | Cellular retinoic acid-binding protein 1 | | Synonym(s): | RABP1_MOUSE
Cellular retinoic acid-binding protein I
CRABP-I
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | P62965 | | UniGene: | Mm.34797 | | SwissProt: | RABP1_MOUSE | | TrEMBL: | | | NCBI (GI): | 51702797 | | Source organism: | Mus musculus (Mouse) | | Sequence length: | 137 | | Percent disordered: | 23% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MPNFAGTWKM RSSENFDELL KALGVNAMLR KVAVAAASKP HVEIRQDGDQ FYIKTSTTVR - 60
TTEINFKVGE GFEEETVDGR KCRSLPTWEN ENKIHCTQTL LEGDGPKTYW TRELANDELI - 120
LTFGADDVVC TRIYVRE
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| Functional narrative |
Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | Alpha 2 | | Location: | 27 - 36 | | Length: | 10 | | Region sequence: |
AMLRKVAVAA | | Modification type: | Fragment
| | PDB: | | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Molecular assembly
| | Functional subclasses: | Protein-protein binding
| Detection methods:
- Hydrogen-deuterium exchange
| References:
- Xiao H, Kaltashov IA. "Transient structural disorder as a facilitator of protein-ligand binding: native h/d exchange-mass spectrometry study of cellular retinoic acid binding protein I." J Am Soc Mass Spectrom. 2005; 16(6): 869-79. PubMed: 15907702
| Comments:
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| Region 2 | | Type: | Disordered | | Name: | Beta 4 | | Location: | 60 - 67 | | Length: | 8 | | Region sequence: |
RTTEINFK | | Modification type: | Fragment
| | PDB: | | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Molecular assembly
| | Functional subclasses: | Protein-protein binding
| Detection methods:
- Hydrogen-deuterium exchange
| References:
- Xiao H, Kaltashov IA. "Transient structural disorder as a facilitator of protein-ligand binding: native h/d exchange-mass spectrometry study of cellular retinoic acid binding protein I." J Am Soc Mass Spectrom. 2005; 16(6): 869-79. PubMed: 15907702
| Comments:
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| Region 3 | | Type: | Disordered | | Name: | Beta 5 | | Location: | 72 - 76 | | Length: | 5 | | Region sequence: |
FEEET | | Modification type: | Fragment
| | PDB: | | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Molecular assembly
| | Functional subclasses: | Protein-protein binding
| Detection methods:
- Hydrogen-deuterium exchange
| References:
- Xiao H, Kaltashov IA. "Transient structural disorder as a facilitator of protein-ligand binding: native h/d exchange-mass spectrometry study of cellular retinoic acid binding protein I." J Am Soc Mass Spectrom. 2005; 16(6): 869-79. PubMed: 15907702
| Comments:
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| Region 4 | | Type: | Disordered | | Name: | Beta 9 | | Location: | 118 - 125 | | Length: | 8 | | Region sequence: |
ELILTFGA | | Modification type: | Fragment
| | PDB: | | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Molecular assembly
| | Functional subclasses: | Protein-protein binding
| Detection methods:
- Hydrogen-deuterium exchange
| References:
- Xiao H, Kaltashov IA. "Transient structural disorder as a facilitator of protein-ligand binding: native h/d exchange-mass spectrometry study of cellular retinoic acid binding protein I." J Am Soc Mass Spectrom. 2005; 16(6): 869-79. PubMed: 15907702
| Comments:
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