| General information | | DisProt: | DP00346 | | Name: | Acetylcholinesterase | | Synonym(s): | ACES_DROME
AChE
EC=3.1.1.7
Acetylcholinesterase 16 kDa subunit [cleavage product 1]
Acetylcholinesterase 55 kDa subunit [cleavage product 2]
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | P07140 | | UniGene: | Dm.1179 | | SwissProt: | ACES_DROME | | TrEMBL: | | | NCBI (GI): | 113036 | | Source organism: | Drosophila melanogaster (Fruit fly) | | Sequence length: | 624 | | Percent disordered: | 5% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MAISCRQSRV LPMSLPLPLT IPLPLVLVLS LHLSGVCGVI DRLVVQTSSG PVRGRSVTVQ - 60
GREVHVYTGI PYAKPPVEDL RFRKPVPAEP WHGVLDATGL SATCVQERYE YFPGFSGEEI - 120
WNPNTNVSED CLYINVWAPA KARLRHGRGA NGGEHPNGKQ ADTDHLIHNG NPQNTTNGLP - 180
ILIWIYGGGF MTGSATLDIY NADIMAAVGN VIVASFQYRV GAFGFLHLAP EMPSEFAEEA - 240
PGNVGLWDQA LAIRWLKDNA HAFGGNPEWM TLFGESAGSS SVNAQLMSPV TRGLVKRGMM - 300
QSGTMNAPWS HMTSEKAVEI GKALINDCNC NASMLKTNPA HVMSCMRSVD AKTISVQQWN - 360
SYSGILSFPS APTIDGAFLP ADPMTLMKTA DLKDYDILMG NVRDEGTYFL LYDFIDYFDK - 420
DDATALPRDK YLEIMNNIFG KATQAEREAI IFQYTSWEGN PGYQNQQQIG RAVGDHFFTC - 480
PTNEYAQALA ERGASVHYYY FTHRTSTSLW GEWMGVLHGD EIEYFFGQPL NNSLQYRPVE - 540
RELGKRMLSA VIEFAKTGNP AQDGEEWPNF SKEDPVYYIF STDDKIEKLA RGPLAARCSF - 600
WNDYLPKVRS WAGTCDGDSG SLAS
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| Functional narrative |
Rapidly hydrolyzes choline released into the synapse. It can hydrolyze butyrylthiocholine.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 142 - 173 | | Length: | 32 | | Region sequence: |
ARLRHGRGANGGEHPNGKQADTDHLIHNGNPQ | | Modification type: | Native
| | PDB: | 1QO9:A | | Structural/functional type: | Relationship to function unknown
| | Functional classes: | | | Functional subclasses: | Unknown
| Detection methods:
- X-ray crystallography (292 K; pH: 4.6; Acetate 0.1 M; Ammonium sulfate 0.1 M; Leucine 0.03 M; MPEG2000 (13%); protein 4 mg/ml)
| References:
- Harel M, Kryger G, Rosenberry TL, Mallender WD, Lewis T, Fletcher RJ, Guss JM, Silman I, Sussman JL. "Three-dimensional structures of Drosophila melanogaster acetylcholinesterase and of its complexes with two potent inhibitors." Protein Sci. 2000; 9(6): 1063-72. PubMed: 10892800
| Comments:
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| Comments |
Positions of the 16 kDa and 55 kDa subunits have not yet been determined. Separate entries may have to be created if the disordered region lies within one or both of the subunits.
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| If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us. |
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