| General information | | DisProt: | DP00350 | | Name: | Chemotaxis protein cheW | | Synonym(s): | CHEW_THEMA
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | Q56311 | | UniGene: | | | SwissProt: | CHEW_THEMA | | TrEMBL: | | | NCBI (GI): | 6225149 | | Source organism: | Thermotoga maritima | | Sequence length: | 151 | | Percent disordered: | 29% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MKTLADALKE FEVLSFEIDE QALAFDVDNI EMVIEKSDIT PVPKSRHFVE GVINLRGRII - 60
PVVNLAKILG ISFDEQKMKS IIVARTKDVE VGFLVDRVLG VLRITENQLD LTNVSDKFGK - 120
KSKGLVKTDG RLIIYLDIDK IIEEITVKEG V
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| Functional narrative |
Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 1 - 9 | | Length: | 9 | | Region sequence: |
MKTLADALK | | Modification type: | Native
| | PDB: | | | Structural/functional type: | Relationship to function unknown
| | Functional classes: | Unknown
| | Functional subclasses: | Unknown
| Detection methods:
- Nuclear magnetic resonance (NMR) (308 K; Sodium acetate (pH 4.5) 50 mM; NaCl 25 mM; Sodium azide (0.02%))
| References:
- Griswold IJ, Zhou H, Matison M, Swanson RV, McIntosh LP, Simon MI, Dahlquist FW. "The solution structure and interactions of CheW from Thermotoga maritima." Nat Struct Biol. 2002; 9(2): 121-5. PubMed: 11799399
| Comments:
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| Region 2 | | Type: | Disordered | | Name: | loop 1 | | Location: | 36 - 49 | | Length: | 14 | | Region sequence: |
KSDITPVPKSRHFV | | Modification type: | Native
| | PDB: | | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Molecular assembly
| | Functional subclasses: | Protein-protein binding
| Detection methods:
- Nuclear magnetic resonance (NMR) (308 K; NaCl 25 mM; Sodium acetate (pH 4.5) 50 mM; Sodium azide (0.02%))
| References:
- Griswold IJ, Zhou H, Matison M, Swanson RV, McIntosh LP, Simon MI, Dahlquist FW. "The solution structure and interactions of CheW from Thermotoga maritima." Nat Struct Biol. 2002; 9(2): 121-5. PubMed: 11799399
| Comments:
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| Region 3 | | Type: | Disordered | | Name: | loop 2 | | Location: | 107 - 123 | | Length: | 17 | | Region sequence: |
NQLDLTNVSDKFGKKSK | | Modification type: | Native
| | PDB: | | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Molecular assembly
| | Functional subclasses: | Unknown
Protein-protein binding
| Detection methods:
- Nuclear magnetic resonance (NMR) (308 K; NaCl 25 mM; Sodium acetate (pH 4.5) 50 mM; Sodium azide (0.02%))
| References:
- Griswold IJ, Zhou H, Matison M, Swanson RV, McIntosh LP, Simon MI, Dahlquist FW. "The solution structure and interactions of CheW from Thermotoga maritima." Nat Struct Biol. 2002; 9(2): 121-5. PubMed: 11799399
| Comments:
|
| Region 4 | | Type: | Disordered | | Name: | | | Location: | 148 - 151 | | Length: | 4 | | Region sequence: |
KEGV | | Modification type: | Native
| | PDB: | | | Structural/functional type: | Relationship to function unknown
| | Functional classes: | Unknown
| | Functional subclasses: | Unknown
| Detection methods:
- Nuclear magnetic resonance (NMR) (308 K; NaCl 25 mM; Sodium acetate (pH 4.5) 50 mM; Sodium azide (0.02%))
| References:
- Griswold IJ, Zhou H, Matison M, Swanson RV, McIntosh LP, Simon MI, Dahlquist FW. "The solution structure and interactions of CheW from Thermotoga maritima." Nat Struct Biol. 2002; 9(2): 121-5. PubMed: 11799399
| Comments:
|
| Region 5 | | Type: | Disordered | | Name: | loop 1 | | Location: | 37 - 49 | | Length: | 13 | | Region sequence: |
SDITPVPKSRHFV | | Modification type: | Native
| | PDB: | | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Molecular assembly
| | Functional subclasses: | Protein-protein binding
| Detection methods:
- Nuclear magnetic resonance (NMR) (308 K; NaCl 25 mM; Sodium acetate (pH 4.5) 50 mM; Sodium azide (0.02%))
| References:
- Griswold IJ, Dahlquist FW. "The dynamic behavior of CheW from Thermotoga maritima in solution, as determined by nuclear magnetic resonance: implications for potential protein-protein interaction sites." Biophys Chem. 2002; 101-102: 359-73. PubMed: 12488014
- Griswold IJ, Zhou H, Matison M, Swanson RV, McIntosh LP, Simon MI, Dahlquist FW. "The solution structure and interactions of CheW from Thermotoga maritima." Nat Struct Biol. 2002; 9(2): 121-5. PubMed: 11799399
| Comments:
|
| Region 6 | | Type: | Disordered | | Name: | loop 2 | | Location: | 109 - 122 | | Length: | 14 | | Region sequence: |
LDLTNVSDKFGKKS | | Modification type: | Native
| | PDB: | | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Molecular assembly
| | Functional subclasses: | Unknown
| Detection methods:
- Nuclear magnetic resonance (NMR) (308 K; NaCl 25 mM; Sodium acetate (pH 4.5) 50 mM; Sodium azide (0.02%))
| References:
- Griswold IJ, Dahlquist FW. "The dynamic behavior of CheW from Thermotoga maritima in solution, as determined by nuclear magnetic resonance: implications for potential protein-protein interaction sites." Biophys Chem. 2002; 101-102: 359-73. PubMed: 12488014
- Griswold IJ, Zhou H, Matison M, Swanson RV, McIntosh LP, Simon MI, Dahlquist FW. "The solution structure and interactions of CheW from Thermotoga maritima." Nat Struct Biol. 2002; 9(2): 121-5. PubMed: 11799399
| Comments:
|
| Region 7 | | Type: | Disordered | | Name: | | | Location: | 150 - 151 | | Length: | 2 | | Region sequence: |
GV | | Modification type: | Native
| | PDB: | | | Structural/functional type: | Relationship to function unknown
| | Functional classes: | Unknown
| | Functional subclasses: | Unknown
| Detection methods:
- Nuclear magnetic resonance (NMR) (308 K; )
| References:
- Griswold IJ, Dahlquist FW. "The dynamic behavior of CheW from Thermotoga maritima in solution, as determined by nuclear magnetic resonance: implications for potential protein-protein interaction sites." Biophys Chem. 2002; 101-102: 359-73. PubMed: 12488014
| Comments:
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