General information | DisProt: | DP00363_A002 | Name: | UDP-N-acetylhexosamine pyrophosphorylase [Isoform AGX1] | Synonym(s): | UAP1_HUMAN
Sperm-associated antigen 2
Antigen X
AGX
UDP-N-acetylgalactosamine pyrophosphorylase [Isoform AGX1]
AGX-1
| First appeared in release: | Release 3.0 (02/17/2006) | UniProt: | Q16222-2 | UniGene: | Hs.492859 | SwissProt: | UAP1_HUMAN | TrEMBL: | | NCBI (GI): | 68846235 | Source organism: | Homo sapiens (Human) | Sequence length: | 505 | Percent disordered: | 3% | Homologues: | |
Native sequence |
10 20 30 40 50 60 | | | | | | MNINDLKLTL SKAGQEHLLR FWNELEEAQQ VELYAELQAM NFEELNFFFQ KAIEGFNQSS - 60 HQKNVDARME PVPREVLGSA TRDQDQLQAW ESEGLFQISQ NKVAVLLLAG GQGTRLGVAY - 120 PKGMYDVGLP SRKTLFQIQA ERILKLQQVA EKYYGNKCII PWYIMTSGRT MESTKEFFTK - 180 HKYFGLKKEN VIFFQQGMLP AMSFDGKIIL EEKNKVSMAP DGNGGLYRAL AAQNIVEDME - 240 QRGIWSIHVY CVDNILVKVA DPRFIGFCIQ KGADCGAKVV EKTNPTEPVG VVCRVDGVYQ - 300 VVEYSEISLA TAQKRSSDGR LLFNAGNIAN HFFTVPFLRD VVNVYEPQLQ HHVAQKKIPY - 360 VDTQGQLIKP DKPNGIKMEK FVFDIFQFAK KFVVYEVLRE DEFSPLKNAD SQNGKDNPTT - 420 ARHALMSLHH CWVLNAGGHF IDENGSRLPA IPRLKDANDV PIQCEISPLI SYAGEGLESY - 480 VADKEFHAPL IIDENGVHEL VKNGI
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Functional narrative |
Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.
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Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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Region 1 | Type: | Disordered | Name: | Loop | Location: | 54 - 68 | Length: | 15 | Region sequence: |
EGFNQSSHQKNVDAR | Modification type: | Isoform
Monomeric
Native
| PDB: | 1JVD:A, 1JVD:B, 1JVG:A, 1JVG:B | Structural/functional type: | Relationship to function unknown | Functional classes: | Unknown
| Functional subclasses: | Unknown
| Detection methods:
- X-ray crystallography (293 K; pH: 5.7; imidazole/malate 0.2 M; PEG600 34 %)
| References:
- Peneff C, Ferrari P, Charrier V, Taburet Y, Monnier C, Zamboni V, Winter J, Harnois M, Fassy F, Bourne Y. "Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture." Embo J. 2001; 20(22): 6191-202. PubMed: 11707391
| Comments:
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