Annotation for this protein is in progress - please check future releases for more complete information



DP00363_A002: UDP-N-acetylhexosamine pyrophosphorylase [Isoform AGX1]FASTA viewXML view

General information
DisProt:DP00363_A002
Name:UDP-N-acetylhexosamine pyrophosphorylase [Isoform AGX1]
Synonym(s):UAP1_HUMAN
Sperm-associated antigen 2
Antigen X
AGX
UDP-N-acetylgalactosamine pyrophosphorylase [Isoform AGX1]
AGX-1
First appeared in release:Release 3.0 (02/17/2006)
UniProt:Q16222-2
UniGene:Hs.492859
SwissProt: UAP1_HUMAN
TrEMBL:  
NCBI (GI): 68846235
Source organism:Homo sapiens (Human)
Sequence length:505
Percent disordered:3%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MNINDLKLTL SKAGQEHLLR FWNELEEAQQ VELYAELQAM NFEELNFFFQ KAIEGFNQSS - 60
HQKNVDARME PVPREVLGSA TRDQDQLQAW ESEGLFQISQ NKVAVLLLAG GQGTRLGVAY - 120
PKGMYDVGLP SRKTLFQIQA ERILKLQQVA EKYYGNKCII PWYIMTSGRT MESTKEFFTK - 180
HKYFGLKKEN VIFFQQGMLP AMSFDGKIIL EEKNKVSMAP DGNGGLYRAL AAQNIVEDME - 240
QRGIWSIHVY CVDNILVKVA DPRFIGFCIQ KGADCGAKVV EKTNPTEPVG VVCRVDGVYQ - 300
VVEYSEISLA TAQKRSSDGR LLFNAGNIAN HFFTVPFLRD VVNVYEPQLQ HHVAQKKIPY - 360
VDTQGQLIKP DKPNGIKMEK FVFDIFQFAK KFVVYEVLRE DEFSPLKNAD SQNGKDNPTT - 420
ARHALMSLHH CWVLNAGGHF IDENGSRLPA IPRLKDANDV PIQCEISPLI SYAGEGLESY - 480
VADKEFHAPL IIDENGVHEL VKNGI



Functional narrative    

Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.

Region 1: 54-68

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:Loop
Location:54 - 68
Length:15
Region sequence:

EGFNQSSHQKNVDAR

Modification type: Isoform
Monomeric
Native
PDB: 1JVD:A, 1JVD:B, 1JVG:A, 1JVG:B
Structural/functional type: Relationship to function unknown
Functional classes: Unknown
Functional subclasses: Unknown
Detection methods:
  1. X-ray crystallography (293 K; pH: 5.7; imidazole/malate 0.2 M; PEG600 34 %)

References:
  1. Peneff C, Ferrari P, Charrier V, Taburet Y, Monnier C, Zamboni V, Winter J, Harnois M, Fassy F, Bourne Y. "Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture." Embo J. 2001; 20(22): 6191-202. PubMed: 11707391

Comments:
 


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