| General information | | DisProt: | DP00377 | | Name: | ProP effector | | Synonym(s): | PROQ_ECOLI
Protein proQ
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | P45577 | | UniGene: | | | SwissProt: | PROQ_ECOLI | | TrEMBL: | | | NCBI (GI): | 6174928 | | Source organism: | Escherichia coli | | Sequence length: | 232 | | Percent disordered: | 23% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MENQPKLNSS KEVIAFLAER FPHCFSAEGE ARPLKIGIFQ DLVDRVAGEM NLSKTQLRSA - 60
LRLYTSSWRY LYGVKPGATR VDLDGNPCGE LDEQHVEHAR KQLEEAKARV QAQRAEQQAK - 120
KREAAATAGE KEDAPRRERK PRPTTPRRKE GAERKPRAQK PVEKAPKTVK APREEQHTPV - 180
SDISALTVGQ ALKVKAGQNA MDATVLEITK DGVRVQLNSG MSLIVRAEHL VF
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| Functional narrative |
Not exactly known; may be a structural element that influences the osmotic activation of proP at a post-translational level.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 125 - 178 | | Length: | 54 | | Region sequence: |
AATAGEKEDAPRRERKPRPTTPRRKEGAERKPRAQKPVEKAPKTVKAPREEQHT | | Modification type: | Native
| | PDB: | | | Structural/functional type: | Function arises from the disordered state
| | Functional classes: | Entropic chain
| | Functional subclasses: | Flexible linkers/spacers
| Detection methods:
- Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7.4; Potassium phosphate buffer 10 mM)
| References:
- Smith MN, Crane RA, Keates RA, Wood JM. "Overexpression, purification, and characterization of ProQ, a posttranslational regulator for osmoregulatory transporter ProP of Escherichia coli." Biochemistry. 2004; 43(41): 12979-89. PubMed: 15476391
| Comments:
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