| General information | | DisProt: | DP00383 | | Name: | Aldehyde dehydrogenase, mitochondrial | | Synonym(s): | ALDH2_HUMAN
EC 1.2.1.3
ALDH class 2
ALDHI
ALDH2
ALDH-E2
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | P05091 | | UniGene: | Hs.632733 | | SwissProt: | ALDH2_HUMAN | | TrEMBL: | | | NCBI (GI): | 118504 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 500 | | Percent disordered: | 9% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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SAAATQAVPA PNQQPEVFCN QIFINNEWHD AVSRKTFPTV NPSTGEVICQ VAEGDKEDVD - 60
KAVKAARAAF QLGSPWRRMD ASHRGRLLNR LADLIERDRT YLAALETLDN GKPYVISYLV - 120
DLDMVLKCLR YYAGWADKYH GKTIPIDGDF FSYTRHEPVG VCGQIIPWNF PLLMQAWKLG - 180
PALATGNVVV MKVAEQTPLT ALYVANLIKE AGFPPGVVNI VPGFGPTAGA AIASHEDVDK - 240
VAFTGSTEIG RVIQVAAGSS NLKRVTLELG GKSPNIIMSD ADMDWAVEQA HFALFFNQGQ - 300
CCCAGSRTFV QEDIYDEFVE RSVARAKSRV VGNPFDSKTE QGPQVDETQF KKILGYINTG - 360
KQEGAKLLCG GGIAADRGYF IQPTVFGDVQ DGMTIAKEEI FGPVMQILKF KTIEEVVGRA - 420
NNSTYGLAAA VFTKDLDKAN YLSQALQAGT VWVNCYDVFG AQSPFGGYKM SGSGRELGEY - 480
GLQAYTEVKT VTVKVPQKNS
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| Functional narrative |
Involved in alcohol metabolism.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 244 - 272 | | Length: | 29 | | Region sequence: |
TGSTEIGRVIQVAAGSSNLKRVTLELGGK | | Modification type: | Mutant
| | PDB: | | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
- X-ray crystallography
| References:
- Larson HN, Weiner H, Hurley TD. "Disruption of the coenzyme binding site and dimer interface revealed in the crystal structure of mitochondrial aldehyde dehydrogenase "Asian" variant." J Biol Chem. 2005; 280(34): 30550-6. PubMed: 15983043
| Comments:
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| Region 2 | | Type: | Disordered | | Name: | | | Location: | 424 - 425 | | Length: | 2 | | Region sequence: |
TY | | Modification type: | Mutant
| | PDB: | | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
- X-ray crystallography
| References:
- Larson HN, Weiner H, Hurley TD. "Disruption of the coenzyme binding site and dimer interface revealed in the crystal structure of mitochondrial aldehyde dehydrogenase "Asian" variant." J Biol Chem. 2005; 280(34): 30550-6. PubMed: 15983043
| Comments:
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| Region 3 | | Type: | Disordered | | Name: | | | Location: | 463 - 478 | | Length: | 16 | | Region sequence: |
SPFGGYKMSGSGRELG | | Modification type: | Mutant
| | PDB: | | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
- X-ray crystallography
| References:
- Larson HN, Weiner H, Hurley TD. "Disruption of the coenzyme binding site and dimer interface revealed in the crystal structure of mitochondrial aldehyde dehydrogenase "Asian" variant." J Biol Chem. 2005; 280(34): 30550-6. PubMed: 15983043
| Comments:
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| Comments |
The sequence listed in NCBI and SwissProt is for the precursor and contains 17 additional residues at the N-terminal.
The disordered regions are only present in the Asian Variant (ALDH2*2) of ALDH2. This variant has an E487K mutation.
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