General information | DisProt: | DP00384 | Name: | High mobility group protein B1 | Synonym(s): | HMGB1_MOUSE
High mobility group protein 1
HMG-1
| First appeared in release: | Release 3.0 (02/17/2006) | UniProt: | P63158 | UniGene: | Mm.207047 | SwissProt: | HMGB1_MOUSE | TrEMBL: | | NCBI (GI): | 52783747 | Source organism: | Mus musculus (Mouse) | Sequence length: | 215 | Percent disordered: | 28% | Homologues: | |
Native sequence |
10 20 30 40 50 60 | | | | | | MGKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF - 60 EDMAKADKAR YEREMKTYIP PKGETKKKFK DPNAPKRPPS AFFLFCSEYR PKIKGEHPGL - 120 SIGDVAKKLG EMWNNTAADD KQPYEKKAAK LKEKYEKDIA AYRAKGKPDA AKKGVVKAEK - 180 SKKKKEEEDD EEDEEDEEEE EEEEDEDEEE DDDDE
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Functional narrative |
Binds preferentially single-stranded DNA and unwinds double stranded DNA. Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells.
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Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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Region 1 | Type: | Disordered | Name: | | Location: | 2 - 4 | Length: | 3 | Region sequence: |
GKG | Modification type: | Native
| PDB: | | Structural/functional type: | | Functional classes: | | Functional subclasses: | Protein-DNA binding
| Detection methods:
- Circular dichroism (CD) spectroscopy, far-UV
- Nuclear magnetic resonance (NMR) (293 K; DTT 10 mM; NaCl 150 mM; Phosphate buffer (pH 5.0) 10 mM)
| References:
- Knapp S, Muller S, Digilio G, Bonaldi T, Bianchi ME, Musco G. "The long acidic tail of high mobility group box 1 (HMGB1) protein forms an extended and flexible structure that interacts with specific residues within and between the HMG boxes." Biochemistry. 2004; 43(38): 11992-7. PubMed: 15379539
| Comments:
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Region 2 | Type: | Disordered | Name: | | Location: | 82 - 90 | Length: | 9 | Region sequence: |
KGETKKKFK | Modification type: | Native
| PDB: | | Structural/functional type: | | Functional classes: | | Functional subclasses: | Protein-DNA binding
| Detection methods:
- Circular dichroism (CD) spectroscopy, far-UV
- Nuclear magnetic resonance (NMR) (293 K; DTT 10 mM; NaCl 150 mM; Phosphate buffer (pH 5.0) 10 mM)
| References:
- Knapp S, Muller S, Digilio G, Bonaldi T, Bianchi ME, Musco G. "The long acidic tail of high mobility group box 1 (HMGB1) protein forms an extended and flexible structure that interacts with specific residues within and between the HMG boxes." Biochemistry. 2004; 43(38): 11992-7. PubMed: 15379539
| Comments:
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Region 3 | Type: | Disordered | Name: | | Location: | 167 - 185 | Length: | 19 | Region sequence: |
KPDAAKKGVVKAEKSKKKK | Modification type: | Native
| PDB: | | Structural/functional type: | | Functional classes: | | Functional subclasses: | Protein-DNA binding
| Detection methods:
- Circular dichroism (CD) spectroscopy, far-UV
- Nuclear magnetic resonance (NMR) (293 K; DTT 10 mM; NaCl 150 mM; Phosphate buffer (pH 5.0) 10 mM)
| References:
- Knapp S, Muller S, Digilio G, Bonaldi T, Bianchi ME, Musco G. "The long acidic tail of high mobility group box 1 (HMGB1) protein forms an extended and flexible structure that interacts with specific residues within and between the HMG boxes." Biochemistry. 2004; 43(38): 11992-7. PubMed: 15379539
| Comments:
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Region 4 | Type: | Disordered | Name: | acidic tail | Location: | 186 - 215 | Length: | 30 | Region sequence: |
EEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | Modification type: | Native
| PDB: | | Structural/functional type: | | Functional classes: | | Functional subclasses: | Protein-DNA binding
| Detection methods:
- Circular dichroism (CD) spectroscopy, far-UV
- Nuclear magnetic resonance (NMR) (293 K; DTT 10 mM; NaCl 150 mM; Phosphate buffer (pH 5.0) 10 mM)
| References:
- Knapp S, Muller S, Digilio G, Bonaldi T, Bianchi ME, Musco G. "The long acidic tail of high mobility group box 1 (HMGB1) protein forms an extended and flexible structure that interacts with specific residues within and between the HMG boxes." Biochemistry. 2004; 43(38): 11992-7. PubMed: 15379539
| Comments:
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Comments |
Additional UniGene ID: Mm.313345
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