| General information | | DisProt: | DP00388 | | Name: | Defensin-related cryptdin-4 | | Synonym(s): | DEF4_MOUSE
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | P28311 | | UniGene: | Mm.465152 | | SwissProt: | DEF4_MOUSE | | TrEMBL: | | | NCBI (GI): | 21542397 | | Source organism: | Mus musculus (Mouse) | | Sequence length: | 92 | | Percent disordered: | 15% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MKTLVLLSAL VLLAFQVQAD PIQNTDEETK TEEQPGEEDQ AVSISFGGQE GSALHEKSLR - 60
GLLCYCRKGH CKRGERVRGT CGIRFLYCCP RR
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| Functional narrative |
Probably contributes to the antimicrobial barrier function of the small bowel mucosa. (UniProt)
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 61 - 64 | | Length: | 4 | | Region sequence: |
GLLC | | Modification type: | Monomeric
| | PDB: | 1TV0:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
- Nuclear magnetic resonance (NMR) (303 K; pH: 4.2; )
| References:
- Jing W, Hunter HN, Tanabe H, Ouellette AJ, Vogel HJ. "Solution structure of cryptdin-4, a mouse paneth cell alpha-defensin." Biochemistry. 2004; 43(50): 15759-66. PubMed: 15595831
| Comments:
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| Region 2 | | Type: | Disordered | | Name: | beta-hairpin loop | | Location: | 69 - 74 | | Length: | 6 | | Region sequence: |
GHCKRG | | Modification type: | Monomeric
| | PDB: | 1TV0:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
- Nuclear magnetic resonance (NMR) (303 K; pH: 4.2; )
| References:
- Jing W, Hunter HN, Tanabe H, Ouellette AJ, Vogel HJ. "Solution structure of cryptdin-4, a mouse paneth cell alpha-defensin." Biochemistry. 2004; 43(50): 15759-66. PubMed: 15595831
| Comments:The flexible hairpin turn may promote increased interactions with the hydrophobic inner regions of bacterial membranes.
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| Region 3 | | Type: | Disordered | | Name: | | | Location: | 89 - 92 | | Length: | 4 | | Region sequence: |
CPRR | | Modification type: | Monomeric
| | PDB: | 1TV0:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
- Nuclear magnetic resonance (NMR) (303 K; pH: 4.2; )
| References:
- Jing W, Hunter HN, Tanabe H, Ouellette AJ, Vogel HJ. "Solution structure of cryptdin-4, a mouse paneth cell alpha-defensin." Biochemistry. 2004; 43(50): 15759-66. PubMed: 15595831
| Comments:
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| Comments |
The mature form of the protein spans from residues 59 to 92. The signal peptide (1 - 19) and the propeptide (20 - 58) are removed to produce the mature form of the protein.
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