| General information | | DisProt: | DP00399 | | Name: | Inosine-5'-monophosphate dehydrogenase | | Synonym(s): | IMDH_TRIFO
IMP dehydrogenase
IMPDH
IMPD
EC 1.1.1.205
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | P50097 | | UniGene: | | | SwissProt: | IMDH_TRIFO | | TrEMBL: | | | NCBI (GI): | 1708475 | | Source organism: | Tritrichomonas foetus (Trichomonas foetus) | | Sequence length: | 503 | | Percent disordered: | 34% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
| | | | | |
MAKYYNEPCH TFNEYLLIPG LSTVDCIPSN VNLSTPLVKF QKGQQSEINL KIPLVSAIMQ - 60
SVSGEKMAIA LAREGGISFI FGSQSIESQA AMVHAVKNFK AGFVVSDSNV KPDQTFADVL - 120
AISQRTTHNT VAVTDDGTPH GVLLGLVTQR DYPIDLTQTE TKVSDMMTPF SKLVTAHQDT - 180
KLSEANKIIW EKKLNALPII DDDQHLRYIV FRKDYDRSQV CHNELVDSQK RYLVGAGINT - 240
RDFRERVPAL VEAGADVLCI DSSDGFSEWQ KITIGWIREK YGDKVKVGAG NIVDGEGFRY - 300
LADAGADFIK IGIGGGSICI TREQKGIGRG QATAVIDVVA ERNKYFEETG IYIPVCSDGG - 360
IVYDYHMTLA LAMGADFIML GRYFARFEES PTRKVTINGS VMKEYWGEGS SRARNWQRYD - 420
LGGKQKLSFE EGVDSYVPYA GKLKDNVEAS LNKVKSTMCN CGALTIPQLQ SKAKITLVSS - 480
VSIVEGGAHD VIVKDRINDY HPK
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| Functional narrative |
Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 102 - 221 | | Length: | 120 | | Region sequence: |
GFVVSDSNVKPDQTFADVLAISQRTTHNTVAVTDDGTPHGVLLGLVTQRDYPIDLTQTET
KVSDMMTPFSKLVTAHQDTKLSEANKIIWEKKLNALPIIDDDQHLRYIVFRKDYDRSQVC
| | Modification type: | Complex
| | PDB: | | | Structural/functional type: | Relationship to function unknown
| | Functional classes: | Unknown
| | Functional subclasses: | Unknown
| Detection methods:
- X-ray crystallography (277 K; Ammonium sulfate 2.2 M)
- X-ray crystallography (277 K; Ammonium sulfate 2.2 M; XMP (30-50 mM))
| References:
- Whitby FG, Luecke H, Kuhn P, Somoza JR, Huete-Perez JA, Phillips JD, Hill CP, Fletterick RJ, Wang CC. "Crystal structure of Tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex." Biochemistry. 1997; 36(35): 10666-74. PubMed: 9271497
| Comments:
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| Region 2 | | Type: | Disordered | | Name: | Glycine-rich loop | | Location: | 314 - 324 | | Length: | 11 | | Region sequence: |
GGGSICITREQ | | Modification type: | Complex
| | PDB: | | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Modification site
| | Functional subclasses: | Substrate/ligand binding
| Detection methods:
- X-ray crystallography (277 K; Ammonium sulfate 2.2 M)
- X-ray crystallography (277 K; Ammonium sulfate 2.2 M; XMP (30-50 mM))
| References:
- Whitby FG, Luecke H, Kuhn P, Somoza JR, Huete-Perez JA, Phillips JD, Hill CP, Fletterick RJ, Wang CC. "Crystal structure of Tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex." Biochemistry. 1997; 36(35): 10666-74. PubMed: 9271497
| Comments:
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| Region 3 | | Type: | Disordered | | Name: | | | Location: | 413 - 431 | | Length: | 19 | | Region sequence: |
ARNWQRYDLGGKQKLSFEE | | Modification type: | Complex
| | PDB: | | | Structural/functional type: | Relationship to function unknown
| | Functional classes: | Unknown
| | Functional subclasses: | Unknown
| Detection methods:
- X-ray crystallography (277 K; Ammonium sulfate 2.2 M)
- X-ray crystallography (277 K; Ammonium sulfate 2.2 M; XMP (30-50 mM))
| References:
- Whitby FG, Luecke H, Kuhn P, Somoza JR, Huete-Perez JA, Phillips JD, Hill CP, Fletterick RJ, Wang CC. "Crystal structure of Tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex." Biochemistry. 1997; 36(35): 10666-74. PubMed: 9271497
| Comments:
|
| Region 4 | | Type: | Disordered | | Name: | | | Location: | 484 - 503 | | Length: | 20 | | Region sequence: |
VEGGAHDVIVKDRINDYHPK | | Modification type: | Complex
| | PDB: | | | Structural/functional type: | Relationship to function unknown
| | Functional classes: | Unknown
| | Functional subclasses: | Unknown
| Detection methods:
- X-ray crystallography (277 K; Ammonium sulfate 2.2 M)
- X-ray crystallography (277 K; Ammonium sulfate 2.2 M; XMP (30-50 mM))
| References:
- Whitby FG, Luecke H, Kuhn P, Somoza JR, Huete-Perez JA, Phillips JD, Hill CP, Fletterick RJ, Wang CC. "Crystal structure of Tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex." Biochemistry. 1997; 36(35): 10666-74. PubMed: 9271497
| Comments:
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