| General information | | DisProt: | DP00404 | | Name: | Sulfotransferase family cytosolic 2B member 1 [Isoform 1 (SULT2B1b)(B)] | | Synonym(s): | ST2B1_HUMAN
Sulfotransferase 2B1
EC 2.8.2.2
Alcohol sulfotransferase
Hydroxysteroid sulfotransferase 2
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | O00204 | | UniGene: | Hs.369331 | | SwissProt: | ST2B1_HUMAN | | TrEMBL: | | | NCBI (GI): | 57013028 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 365 | | Percent disordered: | 4% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MDGPAEPQIP GLWDTYEDDI SEISQKLPGE YFRYKGVPFP VGLYSLESIS LAENTQDVRD - 60
DDIFIITYPK SGTTWMIEII CLILKEGDPS WIRSVPIWER APWCETIVGA FSLPDQYSPR - 120
LMSSHLPIQI FTKAFFSSKA KVIYMGRNPR DVVVSLYHYS KIAGQLKDPG TPDQFLRDFL - 180
KGEVQFGSWF DHIKGWLRMK GKDNFLFITY EELQQDLQGS VERICGFLGR PLGKEALGSV - 240
VAHSTFSAMK ANTMSNYTLL PPSLLDHRRG AFLRKGVCGD WKNHFTVAQS EAFDRAYRKQ - 300
MRGMPTFPWD EDPEEDGSPD PEPSPEPEPK PSLEPNTSLE REPRPNSSPS PSPGQASETP - 360
HPRPS
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| Functional narrative |
Catalyzes the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 14 - 26 | | Length: | 13 | | Region sequence: |
DTYEDDISEISQK | | Modification type: | Complex
Fragment
Isoform
| | PDB: | | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Modification site
| | Functional subclasses: | Substrate/ligand binding
| Detection methods:
- X-ray crystallography (imidazole (pH 8.0 to 8.5) 0.1 M; sodium citrate (0.55 to 0.8 M))
| References:
- Lee KA, Fuda H, Lee YC, Negishi M, Strott CA, Pedersen LC. "Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms." J Biol Chem. 2003; 278(45): 44593-9. PubMed: 12923182
| Comments:
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| References |
- Her C, Wood TC, Eichler EE, Mohrenweiser HW, Ramagli LS, Siciliano MJ, Weinshilboum RM. "Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded by a single chromosome 19 gene." Genomics. 1998; 53(3): 284-95. PubMed: 9799594
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| Comments |
This protein has two different isoforms that contain separate regions of disorder. Isoforms I and II have different amino termini sequences measuring 23 and 8 amino acids in length, respectively.
Previous entry DP00404 has been split into canonical isoform I (DP00404) and isoform II (DP00404_A002).
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