| General information | | DisProt: | DP00407 | | Name: | Chemotaxis protein cheA [Isoform cheA(L)(Long)(Large)] | | Synonym(s): | CHEA_ECOLI
EC=2.7.13.3
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | P07363-1 | | UniGene: | | | SwissProt: | CHEA_ECOLI | | TrEMBL: | | | NCBI (GI): | 2507378 | | Source organism: | Escherichia coli | | Sequence length: | 654 | | Percent disordered: | 10% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MSMDISDFYQ TFFDEADELL ADMEQHLLVL QPEAPDAEQL NAIFRAAHSI KGGAGTFGFS - 60
VLQETTHLME NLLDEARRGE MQLNTDIINL FLETKDIMQE QLDAYKQSQE PDAASFDYIC - 120
QALRQLALEA KGETPSAVTR LSVVAKSEPQ DEQSRSQSPR RIILSRLKAG EVDLLEEELG - 180
HLTTLTDVVK GADSLSAILP GDIAEDDITA VLCFVIEADQ ITFETVEVSP KISTPPVLKL - 240
AAEQAPTGRV EREKTTRSNE STSIRVAVEK VDQLINLVGE LVITQSMLAQ RSSELDPVNH - 300
GDLITSMGQL QRNARDLQES VMSIRMMPME YVFSRYPRLV RDLAGKLGKQ VELTLVGSST - 360
ELDKSLIERI IDPLTHLVRN SLDHGIELPE KRLAAGKNSV GNLILSAEHQ GGNICIEVTD - 420
DGAGLNRERI LAKAASQGLT VSENMSDDEV AMLIFAPGFS TAEQVTDVSG RGVGMDVVKR - 480
NIQKMGGHVE IQSKQGTGTT IRILLPLTLA ILDGMSVRVA DEVFILPLNA VMESLQPREA - 540
DLHPLAGGER VLEVRGEYLP IVELWKVFNV AGAKTEATQG IVVILQSGGR RYALLVDQLI - 600
GQHQVVVKNL ESNYRKVPGI SAATILGDGS VALIVDVSAL QAINREQRMA NTAA
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| Functional narrative |
Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either cheB or cheY.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered - Extended | | Name: | | | Location: | 124 - 158 | | Length: | 35 | | Region sequence: |
RQLALEAKGETPSAVTRLSVVAKSEPQDEQSRSQS | | Modification type: | Fragment
Native
| | PDB: | 1FWP:A | | Structural/functional type: | Function arises from the disordered state
| | Functional classes: | Entropic chain
| | Functional subclasses: | Flexible linkers/spacers
| Detection methods:
- Nuclear magnetic resonance (NMR)
| References:
- McEvoy MM, Muhandiram DR, Kay LE, Dahlquist FW. "Structure and dynamics of a CheY-binding domain of the chemotaxis kinase CheA determined by nuclear magnetic resonance spectroscopy." Biochemistry. 1996; 35(18): 5633-40. PubMed: 8639521
| Comments:The experimental fragment consisted of residues 124-257 of the Swiss Prot sequence.
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| Region 2 | | Type: | Disordered - Extended | | Name: | | | Location: | 228 - 257 | | Length: | 30 | | Region sequence: |
VSPKISTPPVLKLAAEQAPTGRVEREKTTR | | Modification type: | Fragment
Native
| | PDB: | 1FWP:A | | Structural/functional type: | Function arises from the disordered state
| | Functional classes: | Entropic chain
| | Functional subclasses: | Flexible linkers/spacers
| Detection methods:
- Nuclear magnetic resonance (NMR)
| References:
- McEvoy MM, Muhandiram DR, Kay LE, Dahlquist FW. "Structure and dynamics of a CheY-binding domain of the chemotaxis kinase CheA determined by nuclear magnetic resonance spectroscopy." Biochemistry. 1996; 35(18): 5633-40. PubMed: 8639521
| Comments:The experimental fragment consisted of residues 124-257 of the Swiss Prot sequence.
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