Annotation for this protein is in progress - please check future releases for more complete information



DP00482: Sorting nexin-3FASTA viewXML view

General information
DisProt:DP00482
Name:Sorting nexin-3
Synonym(s):SNX3_YEAST
Golgi retention deficient protein 19
First appeared in release:Release 3.1 (03/31/2006)
UniProt:Q08826
UniGene: 
SwissProt: SNX3_YEAST
TrEMBL:  
NCBI (GI): 10720283
Source organism:Saccharomyces cerevisiae (Baker's yeast)
Sequence length:162
Percent disordered:19%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MPREFKSFGS TEKSLLSKGH GEPSYSEIYA EPENFLEIEV HNPKTHIPNG MDSKGMFTDY - 60
EIICRTNLPS FHKRVSKVRR RYSDFEFFRK CLIKEISMLN HPKVMVPHLP GKILLSNRFS - 120
NEVIEERRQG LNTWMQSVAG HPLLQSGSKV LVRFIEAEKF VG



Functional narrative    

Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment.

Region 1: 1-28 Region 2: 114-115

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:1 - 28
Length:28
Region sequence:

MPREFKSFGSTEKSLLSKGHGEPSYSEI

Modification type: Complex
Native
PDB:  
Structural/functional type: Relationship to function unknown
Functional classes: Unknown
Functional subclasses: Unknown
Detection methods:
  1. X-ray crystallography (293 K; pH: 7.5; Na-HEPES 0.1 M; polyethylene glycol 4000 (16%))

  2. X-ray crystallography (293 K; pH: 7.5; ethylene glycol (8%); HEPES 0.1 M; polyethylene glycol 8000 (10%))

References:
  1. Zhou CZ, de La Sierra-Gallay IL, Quevillon-Cheruel S, Collinet B, Minard P, Blondeau K, Henckes G, Aufrere R, Leulliot N, Graille M, Sorel I, Savarin P, de la Torre F, Poupon A, Janin J, van Tilbeurgh H. "Crystal structure of the yeast Phox homology (PX) domain protein Grd19p complexed to phosphatidylinositol-3-phosphate." J Biol Chem. 2003; 278(50): 50371-6. PubMed: 14514667

Comments:
 



Region 2
Type:Disordered
Name: 
Location:114 - 115
Length:2
Region sequence:

LL

Modification type: Complex
PDB:  
Structural/functional type: Function arises via an order to disorder transition
Functional classes: Unknown
Functional subclasses: Substrate/ligand binding
Detection methods:
  1. X-ray crystallography (293 K; pH: 7.5; ethylene glycol (8%); HEPES 0.1 M; polyethylene glycol 8000 (10%))

References:
  1. Zhou CZ, de La Sierra-Gallay IL, Quevillon-Cheruel S, Collinet B, Minard P, Blondeau K, Henckes G, Aufrere R, Leulliot N, Graille M, Sorel I, Savarin P, de la Torre F, Poupon A, Janin J, van Tilbeurgh H. "Crystal structure of the yeast Phox homology (PX) domain protein Grd19p complexed to phosphatidylinositol-3-phosphate." J Biol Chem. 2003; 278(50): 50371-6. PubMed: 14514667

Comments:
 



Comments


The crystal structure of Grd19p, free and in complex with a soluble diC4PtdIns(3)P compound, was determined.


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