| General information | | DisProt: | DP00482 | | Name: | Sorting nexin-3 | | Synonym(s): | SNX3_YEAST
Golgi retention deficient protein 19
| | First appeared in release: | Release 3.1 (03/31/2006) | | UniProt: | Q08826 | | UniGene: | | | SwissProt: | SNX3_YEAST | | TrEMBL: | | | NCBI (GI): | 10720283 | | Source organism: | Saccharomyces cerevisiae (Baker's yeast) | | Sequence length: | 162 | | Percent disordered: | 19% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MPREFKSFGS TEKSLLSKGH GEPSYSEIYA EPENFLEIEV HNPKTHIPNG MDSKGMFTDY - 60
EIICRTNLPS FHKRVSKVRR RYSDFEFFRK CLIKEISMLN HPKVMVPHLP GKILLSNRFS - 120
NEVIEERRQG LNTWMQSVAG HPLLQSGSKV LVRFIEAEKF VG
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| Functional narrative |
Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 1 - 28 | | Length: | 28 | | Region sequence: |
MPREFKSFGSTEKSLLSKGHGEPSYSEI | | Modification type: | Complex
Native
| | PDB: | | | Structural/functional type: | Relationship to function unknown
| | Functional classes: | Unknown
| | Functional subclasses: | Unknown
| Detection methods:
- X-ray crystallography (293 K; pH: 7.5; Na-HEPES 0.1 M; polyethylene glycol 4000 (16%))
- X-ray crystallography (293 K; pH: 7.5; ethylene glycol (8%); HEPES 0.1 M; polyethylene glycol 8000 (10%))
| References:
- Zhou CZ, de La Sierra-Gallay IL, Quevillon-Cheruel S, Collinet B, Minard P, Blondeau K, Henckes G, Aufrere R, Leulliot N, Graille M, Sorel I, Savarin P, de la Torre F, Poupon A, Janin J, van Tilbeurgh H. "Crystal structure of the yeast Phox homology (PX) domain protein Grd19p complexed to phosphatidylinositol-3-phosphate." J Biol Chem. 2003; 278(50): 50371-6. PubMed: 14514667
| Comments:
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| Region 2 | | Type: | Disordered | | Name: | | | Location: | 114 - 115 | | Length: | 2 | | Region sequence: |
LL | | Modification type: | Complex
| | PDB: | | | Structural/functional type: | Function arises via an order to disorder transition
| | Functional classes: | Unknown
| | Functional subclasses: | Substrate/ligand binding
| Detection methods:
- X-ray crystallography (293 K; pH: 7.5; ethylene glycol (8%); HEPES 0.1 M; polyethylene glycol 8000 (10%))
| References:
- Zhou CZ, de La Sierra-Gallay IL, Quevillon-Cheruel S, Collinet B, Minard P, Blondeau K, Henckes G, Aufrere R, Leulliot N, Graille M, Sorel I, Savarin P, de la Torre F, Poupon A, Janin J, van Tilbeurgh H. "Crystal structure of the yeast Phox homology (PX) domain protein Grd19p complexed to phosphatidylinositol-3-phosphate." J Biol Chem. 2003; 278(50): 50371-6. PubMed: 14514667
| Comments:
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| Comments |
The crystal structure of Grd19p, free and in complex with a soluble diC4PtdIns(3)P compound, was determined.
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