Annotations for this protein have been verified by the authors of the corresponding papers


DP00502: B-cell antigen receptor complex-associated protein alpha chain [Isoform 1 (Long)]FASTA viewXML view

General information
DisProt:DP00502
Name:B-cell antigen receptor complex-associated protein alpha chain [Isoform 1 (Long)]
Synonym(s):CD79A_HUMAN
Ig-alpha
MB-1 membrane glycoprotein
Surface IgM-associated protein
Membrane-bound immunoglobulin-associated protein
Antigen CD79a
First appeared in release:Release 3.2 (05/26/2006)
UniProt:P11912-1
UniGene:Hs.631567
SwissProt: CD79A_HUMAN
TrEMBL:  
NCBI (GI): 547896
Source organism:Homo sapiens (Human)
Sequence length:226
Percent disordered:27%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MPGGPGVLQA LPATIFLLFL LSAVYLGPGC QALWMHKVPA SLMVSLGEDA HFQCPHNSSN - 60
NANVTWWRVL HGNYTWPPEF LGPGEDPNGT LIIQNVNKSH GGIYVCRVQE GNESYQQSCG - 120
TYLRVRQPPP RPFLDMGEGT KNRIITAEGI ILLFCAVVPG TLLLFRKRWQ NEKLGLDAGD - 180
EYEDENLYEG LNLDDCSMYE DISRGLQGTY QDVGSLNIGD VQLEKP



Functional narrative    

The B cell antigen receptor (BCR) consists of the membrane-bound immunoglobulin molecule as the antigen-binding subunit and the Ig-alpha/Ig-beta disulfide-linked heterodimer as the signaling subunit. The BCR Ig alpha chain is involved in transmembrane signal transduction. The Ig alpha chain is a membrane, single pass type I membrane protein. This protein was characterized by the analysis of a recombinant soluble fragment of this subunit, corresponding to the cytoplasmic domain of the molecule and containing residues 166-226. Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B cells.

Region 1: 166-226

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:Cytoplasmic domain of the BCR Ig alpha chain
Location:166 - 226
Length:61
Region sequence:

RKRWQNEKLGLDAGDEYEDENLYEGLNLDDCSMYEDISRGLQGTYQDVGSLNIGDVQLEK
P

Modification type: Native
PDB:  
Structural/functional type: Function arises from the disordered state
Functional classes: Molecular recognition effectors
Molecular assembly
Functional subclasses: Polymerization
Phosphorylation
Protein-protein binding
Detection methods:
  1. Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7; PBS)
References:
  1. Sigalov A, Aivazian D, Stern L. "Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif." Biochemistry. 2004; 43(7): 2049-61. PubMed: 14967045
Comments:
 



References

  1. Ha HJ, Kubagawa H, Burrows PD. "Molecular cloning and expression pattern of a human gene homologous to the murine mb-1 gene." J Immunol. 1992; 148(5): 1526-31. PubMed: 1538135


If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us.


Disprot-footer
Contact us