Annotations for this protein have been verified by the authors of the corresponding papers



DP00508: T-cell surface glycoprotein CD3 gamma chainFASTA viewXML view

General information
DisProt:DP00508
Name:T-cell surface glycoprotein CD3 gamma chain
Synonym(s):CD3G_HUMAN
T-cell receptor T3 gamma chain
Antigen CD3g
First appeared in release:Release 3.2 (05/26/2006)
UniProt:P09693
UniGene:Hs.2259
SwissProt: CD3G_HUMAN
TrEMBL:  
NCBI (GI): 115993
Source organism:Homo sapiens (Human)
Sequence length:182
Percent disordered:24%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MEQGKGLAVL ILAIILLQGT LAQSIKGNHL VKVYDYQEDG SVLLTCDAEA KNITWFKDGK - 60
MIGFLTEDKK KWNLGSNAKD PRGMYQCKGS QNKSKPLQVY YRMCQNCIEL NAATISGFLF - 120
AEIVSIFVLA VGVYFIAGQD GVRQSRASDK QTLLPNDQLY QPLKDREDDQ YSHLQGNQLR - 180
RN



Functional narrative    

The CD3 complex mediates signal transduction.

Region 1: 139-182

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:Cytoplasmic domain
Location:139 - 182
Length:44
Region sequence:

QDGVRQSRASDKQTLLPNDQLYQPLKDREDDQYSHLQGNQLRRN

Modification type: Fragment
Native
PDB:  
Structural/functional type: Function arises from the disordered state
Functional classes: Molecular recognition effectors
Molecular assembly
Functional subclasses: Polymerization
Phosphorylation
Protein-protein binding
Detection methods:
  1. Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7.4; )

References:
  1. Sigalov A, Aivazian D, Stern L. "Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif." Biochemistry. 2004; 43(7): 2049-61. PubMed: 14967045

Comments:
 



References

  1. Krissansen GW, Owen MJ, Verbi W, Crumpton MJ. "Primary structure of the T3 gamma subunit of the T3/T cell antigen receptor complex deduced from cDNA sequences: evolution of the T3 gamma and delta subunits." Embo J. 1986; 5(8): 1799-808. PubMed: 2944745


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