| General information | | DisProt: | DP00508 | | Name: | T-cell surface glycoprotein CD3 gamma chain | | Synonym(s): | CD3G_HUMAN
T-cell receptor T3 gamma chain
Antigen CD3g
| | First appeared in release: | Release 3.2 (05/26/2006) | | UniProt: | P09693 | | UniGene: | Hs.2259 | | SwissProt: | CD3G_HUMAN | | TrEMBL: | | | NCBI (GI): | 115993 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 182 | | Percent disordered: | 24% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MEQGKGLAVL ILAIILLQGT LAQSIKGNHL VKVYDYQEDG SVLLTCDAEA KNITWFKDGK - 60
MIGFLTEDKK KWNLGSNAKD PRGMYQCKGS QNKSKPLQVY YRMCQNCIEL NAATISGFLF - 120
AEIVSIFVLA VGVYFIAGQD GVRQSRASDK QTLLPNDQLY QPLKDREDDQ YSHLQGNQLR - 180
RN
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| Functional narrative |
The CD3 complex mediates signal transduction.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | Cytoplasmic domain | | Location: | 139 - 182 | | Length: | 44 | | Region sequence: |
QDGVRQSRASDKQTLLPNDQLYQPLKDREDDQYSHLQGNQLRRN | | Modification type: | Fragment
Native
| | PDB: | | | Structural/functional type: | Function arises from the disordered state
| | Functional classes: | Molecular recognition effectors
Molecular assembly
| | Functional subclasses: | Polymerization
Phosphorylation
Protein-protein binding
| Detection methods:
- Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7.4; )
| References:
- Sigalov A, Aivazian D, Stern L. "Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif." Biochemistry. 2004; 43(7): 2049-61. PubMed: 14967045
| Comments:
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| References |
- Krissansen GW, Owen MJ, Verbi W, Crumpton MJ. "Primary structure of the T3 gamma subunit of the T3/T cell antigen receptor complex deduced from cDNA sequences: evolution of the T3 gamma and delta subunits." Embo J. 1986; 5(8): 1799-808. PubMed: 2944745
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