| General information | | DisProt: | DP00515 | | Name: | Serum albumin [Isoform 1] | | Synonym(s): | ALBU_HUMAN
| | First appeared in release: | Release 3.6 (06/29/2007) | | UniProt: | P02768-1 | | UniGene: | Hs.418167 | | SwissProt: | ALBU_HUMAN | | TrEMBL: | | | NCBI (GI): | 113576 | | Source organism: | Homo Sapiens (Human) | | Sequence length: | 609 | | Percent disordered: | 1% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MKWVTFISLL FLFSSAYSRG VFRRDAHKSE VAHRFKDLGE ENFKALVLIA FAQYLQQCPF - 60
EDHVKLVNEV TEFAKTCVAD ESAENCDKSL HTLFGDKLCT VATLRETYGE MADCCAKQEP - 120
ERNECFLQHK DDNPNLPRLV RPEVDVMCTA FHDNEETFLK KYLYEIARRH PYFYAPELLF - 180
FAKRYKAAFT ECCQAADKAA CLLPKLDELR DEGKASSAKQ RLKCASLQKF GERAFKAWAV - 240
ARLSQRFPKA EFAEVSKLVT DLTKVHTECC HGDLLECADD RADLAKYICE NQDSISSKLK - 300
ECCEKPLLEK SHCIAEVEND EMPADLPSLA ADFVESKDVC KNYAEAKDVF LGMFLYEYAR - 360
RHPDYSVVLL LRLAKTYETT LEKCCAAADP HECYAKVFDE FKPLVEEPQN LIKQNCELFE - 420
QLGEYKFQNA LLVRYTKKVP QVSTPTLVEV SRNLGKVGSK CCKHPEAKRM PCAEDYLSVV - 480
LNQLCVLHEK TPVSDRVTKC CTESLVNRRP CFSALEVDET YVPKEFNAET FTFHADICTL - 540
SEKERQIKKQ TALVELVKHK PKATKEQLKA VMDDFAAFVE KCCKADDKET CFAEEGKKLV - 600
AASQAALGL
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| Functional narrative |
Human serum albumin is an important transport protein composed primarily of unsaturated fatty acids. HSA protein is composed of seven binding sites all having different affinities for ligand binding. Moreover, the greater the number of configuration sites (i.e., higher disorder) the smaller the affinity for the ligand, and vice versa. Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 1 - 4 | | Length: | 4 | | Region sequence: |
MKWV | | Modification type: | Native
| | PDB: | | | Structural/functional type: | Relationship to function unknown
| | Functional classes: | | | Functional subclasses: | | Detection methods:
- X-ray crystallography
| References:
- Sugio S, Kashima A, Mochizuki S, Noda M, Kobayashi K. "Crystal structure of human serum albumin at 2.5 A resolution." Protein Eng. 1999; 12(6): 439-46. PubMed: 10388840
| Comments:
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| Region 2 | | Type: | Disordered | | Name: | | | Location: | 583 - 585 | | Length: | 3 | | Region sequence: |
CKA | | Modification type: | Native
| | PDB: | | | Structural/functional type: | Function arises from the disordered state
| | Functional classes: | | | Functional subclasses: | Flexible linkers/spacers
| Detection methods:
- X-ray crystallography
| References:
- Sugio S, Kashima A, Mochizuki S, Noda M, Kobayashi K. "Crystal structure of human serum albumin at 2.5 A resolution." Protein Eng. 1999; 12(6): 439-46. PubMed: 10388840
| Comments:
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| References |
- Lawn RM, Adelman J, Bock SC, Franke AE, Houck CM, Najarian RC, Seeburg PH, Wion KL. "The sequence of human serum albumin cDNA and its expression in E. coli." Nucleic Acids Res. 1981; 9(22): 6103-114. PubMed: 6171778
- Petitpas I, Grüne T, Bhattacharya AA, Curry S. "Crystal structures of human serum albumin complexed with monounsaturated and polyunsaturated fatty acids." J Mol Biol. 2001; 314(5): 955-60. PubMed: 11743713
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