| General information | | DisProt: | DP00527 | | Name: | Seminal vesicle secretory protein 4 | | Synonym(s): | SVS4_RAT
Seminal vesicle secretory protein IV
SVS IV
SVS protein S
Seminal vesicle protein 2
Androgen-dependent protein
ADP
| | First appeared in release: | Release 4.1 (07/10/2008) | | UniProt: | P02783 | | UniGene: | Rn.9942 | | SwissProt: | SVS4_RAT | | TrEMBL: | | | NCBI (GI): | 135072 | | Source organism: | Rattus norvegicus (Rat) | | Sequence length: | 112 | | Percent disordered: | 81% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MKSTSLFLCS LLLLLVTGAI GRKTKEKYSQ SEEVVSESFA SGPSSGSSDD ELVRDKPYGP - 60
KVSGGSFGEE ASEEISSRRS KHISRSSGGS NMEGESSYAK KKRSRFAQDV LN
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| Functional narrative |
Potent immunomodulatory and anti-inflammatory secretory protein which promotes nitric oxide production. The immunomodulatory protein SV-IV protects serum-deprived cells against apoptosis but not against G0/G1 arrest: possible implications for the survival of implanting embryos.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | mature protein (post-processing) | | Location: | 22 - 112 | | Length: | 91 | | Region sequence: |
RKTKEKYSQSEEVVSESFASGPSSGSSDDELVRDKPYGPKVSGGSFGEEASEEISSRRSK
HISRSSGGSNMEGESSYAKKKRSRFAQDVLN | | Modification type: | Native
| | PDB: | | | Structural/functional type: | | | Functional classes: | Modification site
Molecular assembly
| | Functional subclasses: | Phosphorylation
Protein-protein binding
Acetylation
| Detection methods:
- SDS-PAGE gel, Aberrant mobility on
- Circular dichroism (CD) spectroscopy, far-UV
- Fluorescence polarization/anisotropy
- Size exclusion/gel filtration chromatography
- Sensitivity to proteolysis
| References:
- Caporale C, Caruso C, Colonna G, Facchiano A, Ferranti P, Mamone G, Picariello G, Colonna F, Metafora S, Stiuso P. "Structural properties of the protein SV-IV." Eur J Biochem. 2004; 271(2): 263-71. PubMed: 14717694
- Metafora S, Esposito C, Caputo I, Lepretti M, Cassese D, Dicitore A, Ferranti P, Stiuso P. "Seminal vesicle protein IV and its derived active peptides: a possible physiological role in seminal clotting." Semin Thromb Hemost. 2007; 33(1): 53-9. PubMed: 17253190
- Stiuso P, Metafora S, Facchiano AM, Colonna G, Ragone R. "The self-association of protein SV-IV and its possible functional implications." Eur J Biochem. 1999; 266(3): 1029-35. PubMed: 10583398
- Vilasi S, Ragone R. "Abundance of intrinsic disorder in SV-IV, a multifunctional androgen-dependent protein secreted from rat seminal vesicle." FEBS J. 2008; 275(4): 763-764. PubMed: 18215165
| Comments:
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| References |
- Mansson PE, Sugino A, Harris SE. "Use of a cloned double stranded cDNA coding for a major androgen dependent protein in rat seminal vesicle secretion: the effect of testosterone in gene expression." Nucleic Acids Res. 1981; 9: 935-946. PubMed: 6164983
- Pan YC, Silverberg AB, Harris SE, Li SS. "Complete amino acid sequence of a major secretory protein from rat seminal vesicle." Int J Pept Protein Res. 1980; 16: 143-146. PubMed: 7007263
- Prevete N, Rossi FW, Triggiani M, Marone G, de Paulis A, Metafora V, De Maria S, Carteni M, Ragone R, Ravagnan G, Metafora S. "Antiapoptotic Seminal Vesicle Protein IV Induces Histamine Release from Human FcepsilonRI+ Cells." Int Arch Allergy Immunol. 2009; 151(4): 318-330. PubMed: 19851073
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