DP00551: Natriuretic peptides BFASTA viewXML view

General information
DisProt:DP00551
Name:Natriuretic peptides B
Synonym(s):ANFB_HUMAN
Gamma-brain natriuretic peptide
Brain natriuretic peptide 32 [cleavage product 1]
BNP-32
BNP(1-32)
BNP(1-30) [cleavage product 2]
BNP(1-29) [cleavage product 3]
BNP(1-28) [cleavage product 4]
BNP(2-31) [cleavage product 5]
BNP(3-32) [cleavage product 6]
BNP(3-30) [cleavage product 7]
BNP(3-29) [cleavage product 8]
BNP(4-32) [cleavage product 9]
BNP(4-31) [cleavage product 10]
BNP(4-30) [cleavage product 11]
BNP(4-29) [cleavage product 12]
BNP(4-27) [cleavage product 13]
BNP(5-32) [cleavage product 14]
BNP(5-31) [cleavage product 15]
BNP(5-29) [cleavage product 16]
First appeared in release:Release 4.9 (01/06/2009)
UniProt:P16860
UniGene:Hs.219140
SwissProt: ANFB_HUMAN
TrEMBL:  
NCBI (GI): 113836
Source organism:Homo sapiens (Human)
Sequence length:134
Percent disordered:76%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MDPQTAPSRA LLLLLFLHLA FLGGRSHPLG SPGSASDLET SGLQEQRNHL QGKLSELQVE - 60
QTSLEPLQES PRPTGVWKSR EVATEGIRGH RKMVLYTLRA PRSPKMVQGS GCFGRKMDRI - 120
SSSSGLGCKV LRRH



Functional narrative    

Acts as a cardiac hormone with a variety of biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. It is thought to play a key role in cardiovascular homeostasis. Helps restore the body's salt and water balance. Improves heart function.

Region 1: 1-102

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:N-terminal proBNP (NT-proBNP)
Location:1 - 102
Length:102
Region sequence:

MDPQTAPSRALLLLLFLHLAFLGGRSHPLGSPGSASDLETSGLQEQRNHLQGKLSELQVE
QTSLEPLQESPRPTGVWKSREVATEGIRGHRKMVLYTLRAPR

Modification type: Fragment
PDB:  
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Crimmins DL, Kao JL. "The human cardiac hormone fragment N-terminal pro B-type natriuretic peptide is an intrinsically unstructured protein." Arch Biochem Biophys. 2007; 461(2): 242-6. PubMed: 17399679
Comments:
 



Comments


All cleavage products begin at residue 103 or higher, which is outside of the disordered region (1-102). Individual entries for each of these products will not be necessary.


If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us.


Disprot-footer
Contact us