| General information | | DisProt: | DP00555 | | Name: | Beta-synuclein | | Synonym(s): | SYUB_HUMAN
BetaS
| | First appeared in release: | Release 4.9 (01/06/2009) | | UniProt: | Q16143 | | UniGene: | Hs.90297 | | SwissProt: | SYUB_HUMAN | | TrEMBL: | | | NCBI (GI): | 546912 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 134 | | Percent disordered: | 100% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ GVASVAEKTK - 60
EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQ EAAEEPLIEP LMEPEGESYE - 120
DPPQEEYQEY EPEA
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| Functional narrative |
BetaS is the non-amyloid component of senile plaques found in Alzheimer disease. It could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6 hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. It was not found in the Lewy bodies associated with Parkinson disease.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered - Extended | | Name: | | | Location: | 1 - 134 | | Length: | 134 | | Region sequence: |
MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTK
EQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYE
DPPQEEYQEYEPEA | | Modification type: | Native
| | PDB: | | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
- Nuclear magnetic resonance (NMR)
| References:
- Bertoncini CW, Rasia RM, Lamberto GR, Binolfi A, Zweckstetter M, Griesinger C, Fernandez CO. "Structural characterization of the intrinsically unfolded protein beta-synuclein, a natural negative regulator of alpha-synuclein aggregation." J Mol Biol. 2007; 372(3): 708-22. PubMed: 17681539
| Comments:
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