| General information | | DisProt: | DP00559 | | Name: | Chorismate synthase | | Synonym(s): | AROC_AQUAE
EC=4.2.3.5
5-enolpyruvylshikimate-3-phosphate phospholyase
| | First appeared in release: | Release 4.0 (06/23/2008) | | UniProt: | O66493 | | UniGene: | | | SwissProt: | AROC_AQUAE | | TrEMBL: | | | NCBI (GI): | 6225067 | | Source organism: | Aquifex aeolicus | | Sequence length: | 398 | | Percent disordered: | 16% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MSLRYLRFLT AGESHGKGLT AILEGIPANL PLSEEEINHE LRRRQRGYGR GGRMKIEKDT - 60
AEILSGVRFG KTLGSPIALF IRNRDWENWK EKMAIEGEPS PSVVPFTRPR PGHADLSGGI - 120
KYNQRDLRNI LERASARETA ARVAVGAVCK KFLSEFGIKI GSFVVSIGQK EVEELKDKSY - 180
FANPEKLLSY HEKAEDSELR IPFPEKDEEF KTYIDEVKEK GESLGGVFEV FALNVPPGLG - 240
SHIQWDRRID GRIAQAMMSI QAIKGVEIGL GFEAARRFGS QVHDEIGWSE GKGYFRHSNN - 300
LGGTEGGITN GMPIVVRVAM KPIPTLKNPL RSVDIETKEE MKAGKERTDI VAVPAASVVG - 360
EAMLAIVLAD ALLEKLGGDF MEEVKKRFED YVNHVKSF
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| Functional narrative |
Catalyzes the final step of the Shikimate Biosynthetic pathway, which is used for the biosynthesis of large aromatic compounds (i.e., aromatic amino acids and secondary metabolites in plants). Disordered loops detected by x-ray crystallography for residues 50-56, 87-117, and 326-350.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 87 - 117 | | Length: | 31 | | Region sequence: |
ENWKEKMAIEGEPSPSVVPFTRPRPGHADLS | | Modification type: | Native
| | PDB: | 1Q1L:A | | Structural/functional type: | | | Functional classes: | Modification site
| | Functional subclasses: | | Detection methods:
- X-ray crystallography (100 K; pH: 7.5; Isopropanol 30 %; Magnesium Chloride 0.2 M; Sodium HEPES 0.1 M)
| References:
There are no documents referencing this region. | Comments:
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| Region 2 | | Type: | Disordered | | Name: | | | Location: | 50 - 56 | | Length: | 7 | | Region sequence: |
RGGRMKI | | Modification type: | Native
| | PDB: | 1Q1L:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
- X-ray crystallography (100 K; pH: 7.5; Isopropanol 30 %; Magnesium Chloride 0.2 M; Sodium HEPES 0.1 M)
| References:
There are no documents referencing this region. | Comments:
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| Region 3 | | Type: | Disordered | | Name: | | | Location: | 326 - 350 | | Length: | 25 | | Region sequence: |
LKNPLRSVDIETKEEMKAGKERTDI | | Modification type: | Native
| | PDB: | 1Q1L:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
- X-ray crystallography (100 K; pH: 7.5; Isopropanol 30 %; Magnesium Chloride 0.2 M; Sodium HEPES 0.1 M)
| References:
There are no documents referencing this region. | Comments:
|
| References |
- Viola CM, Saridakis V, Christendat D. "Crystal structure of chorismate synthase from Aquifex aeolicus reveals a novel beta alpha beta sandwich topology." Proteins. 2004; 54(1): 166-9. PubMed: 14705034
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