| General information | | DisProt: | DP00570 | | Name: | Signal recognition particle 19 kDa protein | | Synonym(s): | SRP19_HUMAN
SRP19
| | First appeared in release: | Release 4.1 (07/10/2008) | | UniProt: | P09132 | | UniGene: | Hs.637001 | | SwissProt: | SRP19_HUMAN | | TrEMBL: | | | NCBI (GI): | 115502457 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 144 | | Percent disordered: | 7% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MACAAARSPA DQDRFICIYP AYLNNKKTIA EGRRIPISKA VENPTATEIQ DVCSAVGLNV - 60
FLEKNKMYSR EWNRDVQYRG RVRVQLKQED GSLCLVQFPS RKSVMLYAAE MIPKLKTRTQ - 120
KTGGADQSLQ QGEGSKKGKG KKKK
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| Functional narrative |
Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 119 - 128 | | Length: | 10 | | Region sequence: |
TQKTGGADQS | | Modification type: | Native
| | PDB: | 1JID:A | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Modification site
| | Functional subclasses: | Protein-genomic RNA binding
Substrate/ligand binding
| Detection methods:
| References:
- Maity TS, Weeks KM. "A threefold RNA-protein interface in the signal recognition particle gates native complex assembly." J Mol Biol. 2007; 369(2): 512-24. PubMed: 17434535
| Comments:
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| References |
- Maity TS, Weeks KM. "A threefold RNA-protein interface in the signal recognition particle gates native complex assembly." J Mol Biol. 2007; 369(2): 512-24. PubMed: 17434535
- Oubridge C, Kuglstatter A, Jovine L, Nagai K. "Crystal structure of SRP19 in complex with the S domain of SRP RNA and its implication for the assembly of the signal recognition particle." Mol Cell. 2002; 9(6): 1251-61. PubMed: 12086622
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