| General information | | DisProt: | DP00575 | | Name: | Alkylmercury lyase | | Synonym(s): | MERB_ECOLX
Organomercurial lyase
| | First appeared in release: | Release 4.5 (07/17/2008) | | UniProt: | P77072 | | UniGene: | | | SwissProt: | MERB_ECOLX | | TrEMBL: | | | NCBI (GI): | 37080207 | | Source organism: | Escherichia coli | | Sequence length: | 212 | | Percent disordered: | 24% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MKLAPYILEL LTSVNRTNGT ADLLVPLLRE LAKGRPVSRT TLAGILDWPA ERVAAVLEQA - 60
TSTEYDKDGN IIGYGLTLRE TSYVFEIDDR RLYAWCALDT LIFPALIGRT ARVSSHCAAT - 120
GAPVSLTVSP SEIQAVEPAG MAVSLVLPQE AADVRQSFCC HVHFFASVPT AEDWASKHQG - 180
LEGLAIVSVH EAFGLGQEFN RHLLQTMSSR TP
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| Functional narrative |
Cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate. One product is Hg2+, which is subsequently detoxified by the mercuric reductase.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 1 - 20 | | Length: | 20 | | Region sequence: |
MKLAPYILELLTSVNRTNGT | | Modification type: | Native
| | PDB: | 1S6L:A | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Unknown
| | Functional subclasses: | Unknown
| Detection methods:
| References:
There are no documents referencing this region. | Comments:
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| Region 2 | | Type: | Disordered | | Name: | | | Location: | 205 - 212 | | Length: | 8 | | Region sequence: |
QTMSSRTP | | Modification type: | Native
| | PDB: | 1S6L:A | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Unknown
| | Functional subclasses: | Unknown
| Detection methods:
| References:
There are no documents referencing this region. | Comments:
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| Region 3 | | Type: | Disordered | | Name: | | | Location: | 146 - 161 | | Length: | 16 | | Region sequence: |
VLPQEAADVRQSFCCH | | Modification type: | Native
| | PDB: | 1S6L:A | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Unknown
| | Functional subclasses: | Flexible linkers/spacers
| Detection methods:
| References:
There are no documents referencing this region. | Comments:
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| Region 4 | | Type: | Disordered | | Name: | | | Location: | 178 - 184 | | Length: | 7 | | Region sequence: |
HQGLEGL | | Modification type: | Native
| | PDB: | 1S6L:A | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Unknown
| | Functional subclasses: | Flexible linkers/spacers
| Detection methods:
| References:
There are no documents referencing this region. | Comments:
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| References |
- Di Lello P, Benison GC, Valafar H, Pitts KE, Summers AO, Legault P, Omichinski JG. "NMR structural studies reveal a novel protein fold for MerB, the organomercurial lyase involved in the bacterial mercury resistance system." Biochemistry. 2004; 43(26): 8322-32. PubMed: 15222745
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