General information | DisProt: | DP00576 | Name: | Ataxin-3 [Isoform 1] | Synonym(s): | ATX3_HUMAN
Machado-Joseph disease protein 1
Spinocerebellar ataxia type 3 protein
| First appeared in release: | Release 4.5 (07/17/2008) | UniProt: | P54252-1 | UniGene: | Hs.532632 | SwissProt: | ATX3_HUMAN | TrEMBL: | | NCBI (GI): | 215274161 | Source organism: | Homo sapiens (Human) | Sequence length: | 376 | Percent disordered: | 11% | Homologues: | |
Native sequence |
10 20 30 40 50 60 | | | | | | MESIFHEKQE GSLCAQHCLN NLLQGEYFSP VELSSIAHQL DEEERMRMAE GGVTSEDYRT - 60 FLQQPSGNMD DSGFFSIQVI SNALKVWGLE LILFNSPEYQ RLRIDPINER SFICNYKEHW - 120 FTVRKLGKQW FNLNSLLTGP ELISDTYLAL FLAQLQQEGY SIFVVKGDLP DCEADQLLQM - 180 IRVQQMHRPK LIGEELAQLK EQRVHKTDLE RMLEANDGSG MLDEDEEDLQ RALALSRQEI - 240 DMEDEEADLR RAIQLSMQGS SRNISQDMTQ TSGTNLTSEE LRKRREAYFE KQQQKQQQQQ - 300 QQQQQQQQQQ QQQQQQQRDL SGQSSHPCER PATSSGALGS DLGKACSPFI MFATFTLYLT - 360 YELHVIFALH YSSFPL
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Functional narrative |
Interacts with key regulators (CBP, p300 and PCAF) of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription. Acts as a deubiquitinating enzyme.
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Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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Region 1 | Type: | Disordered | Name: | | Location: | 144 - 164 | Length: | 21 | Region sequence: |
SDTYLALFLAQLQQEGYSIFV | Modification type: | Native
| PDB: | 1YZB:A, 2AGA:A, 2DOS:A | Structural/functional type: | Function arises via a disorder to order transition | Functional classes: | Modification site
| Functional subclasses: | Autoregulatory
Flexible linkers/spacers
| Detection methods: | References:
There are no documents referencing this region. | Comments:
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Region 2 | Type: | Disordered | Name: | | Location: | 79 - 100 | Length: | 22 | Region sequence: |
VISNALKVWGLELILFNSPEYQ | Modification type: | Native
| PDB: | 1YZB:A, 2AGA:A, 2DOS:A | Structural/functional type: | Function arises via a disorder to order transition | Functional classes: | Modification site
| Functional subclasses: | Autoregulatory
Flexible linkers/spacers
| Detection methods: | References:
There are no documents referencing this region. | Comments:
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References |
- Albrecht M, Golatta M, Wüllner U, Lengauer T. "Structural and functional analysis of ataxin-2 and ataxin-3." Eur J Biochem. 2004; 271(15): 3155-70. PubMed: 15265035
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