Annotation for this protein is in progress - please check future releases for more complete information



DP00576: Ataxin-3 [Isoform 1]FASTA viewXML view

General information
DisProt:DP00576
Name:Ataxin-3 [Isoform 1]
Synonym(s):ATX3_HUMAN
Machado-Joseph disease protein 1
Spinocerebellar ataxia type 3 protein
First appeared in release:Release 4.5 (07/17/2008)
UniProt:P54252-1
UniGene:Hs.532632
SwissProt: ATX3_HUMAN
TrEMBL:  
NCBI (GI): 215274161
Source organism:Homo sapiens (Human)
Sequence length:376
Percent disordered:11%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MESIFHEKQE GSLCAQHCLN NLLQGEYFSP VELSSIAHQL DEEERMRMAE GGVTSEDYRT - 60
FLQQPSGNMD DSGFFSIQVI SNALKVWGLE LILFNSPEYQ RLRIDPINER SFICNYKEHW - 120
FTVRKLGKQW FNLNSLLTGP ELISDTYLAL FLAQLQQEGY SIFVVKGDLP DCEADQLLQM - 180
IRVQQMHRPK LIGEELAQLK EQRVHKTDLE RMLEANDGSG MLDEDEEDLQ RALALSRQEI - 240
DMEDEEADLR RAIQLSMQGS SRNISQDMTQ TSGTNLTSEE LRKRREAYFE KQQQKQQQQQ - 300
QQQQQQQQQQ QQQQQQQRDL SGQSSHPCER PATSSGALGS DLGKACSPFI MFATFTLYLT - 360
YELHVIFALH YSSFPL



Functional narrative    

Interacts with key regulators (CBP, p300 and PCAF) of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription. Acts as a deubiquitinating enzyme.

Region 2: 79-100 Region 1: 144-164

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:144 - 164
Length:21
Region sequence:

SDTYLALFLAQLQQEGYSIFV

Modification type: Native
PDB: 1YZB:A, 2AGA:A, 2DOS:A
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Modification site
Functional subclasses: Autoregulatory
Flexible linkers/spacers
Detection methods:
 
References:
There are no documents referencing this region.
Comments:
 



Region 2
Type:Disordered
Name: 
Location:79 - 100
Length:22
Region sequence:

VISNALKVWGLELILFNSPEYQ

Modification type: Native
PDB: 1YZB:A, 2AGA:A, 2DOS:A
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Modification site
Functional subclasses: Autoregulatory
Flexible linkers/spacers
Detection methods:
 
References:
There are no documents referencing this region.
Comments:
 



References

  1. Albrecht M, Golatta M, W├╝llner U, Lengauer T. "Structural and functional analysis of ataxin-2 and ataxin-3." Eur J Biochem. 2004; 271(15): 3155-70. PubMed: 15265035


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