| General information | | DisProt: | DP00613 | | Name: | Resistance to inhibitors of cholinesterase protein 3 | | Synonym(s): | RIC3_CAEEL
RIC-3
| | First appeared in release: | Release 5.1 (05/28/2010) | | UniProt: | Q22472 | | UniGene: | Cel.6773 | | SwissProt: | RIC3_CAEEL | | TrEMBL: | | | NCBI (GI): | 74966101 | | Source organism: | Caenorhabditis elegans | | Sequence length: | 378 | | Percent disordered: | 100% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MPKTERRRDR DRDRDRERRN RRKRDDSYDD YDEEGGISGW KLGLVFGVIV VCFAMLYPTL - 60
FHPMLMGFLG RSPPSSPSIN QQRPPIHPAM GGGSGQRHPG GGADVHPAMR MAQAQAESQS - 120
GGSKGMFTWM LPVYTIGVVL FLLYTLFKSK GKKSKRKKRN YFDSEDDDDE SESETKYGGK - 180
FGKKKLEGLQ KRLRETESAM SKILEQLESV QAGANPVDLD AADKRSEQLE EDPSVKEAVG - 240
LTETNEQYIK DLEVALKEFQ SLSKEYDKAK MKKLKRKDSS SDEDEEDEEE NSSELSEIEE - 300
EEEEVKPVKK SKSSSQSVGK RKNRPKSTSE EEDEGEEESR KVAEDAEEEG IDIDSEIREH - 360
AEKEKKDKNV RRRRPKKT
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| Functional narrative |
Required for maturation and cell surface expression of acetylcholine receptors.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 1 - 378 | | Length: | 378 | | Region sequence: |
MPKTERRRDRDRDRDRERRNRRKRDDSYDDYDEEGGISGWKLGLVFGVIVVCFAMLYPTL
FHPMLMGFLGRSPPSSPSINQQRPPIHPAMGGGSGQRHPGGGADVHPAMRMAQAQAESQS
GGSKGMFTWMLPVYTIGVVLFLLYTLFKSKGKKSKRKKRNYFDSEDDDDESESETKYGGK
FGKKKLEGLQKRLRETESAMSKILEQLESVQAGANPVDLDAADKRSEQLEEDPSVKEAVG
LTETNEQYIKDLEVALKEFQSLSKEYDKAKMKKLKRKDSSSDEDEEDEEENSSELSEIEE
EEEEVKPVKKSKSSSQSVGKRKNRPKSTSEEEDEGEEESRKVAEDAEEEGIDIDSEIREH
AEKEKKDKNVRRRRPKKT | | Modification type: | Native
| | PDB: | | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Chaperones
| | Functional subclasses: | Protein-protein binding
| Detection methods:
- Immunochemistry
| References:
- Cohen Ben-Ami H, Biala Y, Farah H, Elishevitz E, Battat E, Treinin M. "Receptor and subunit specific interactions of RIC-3 with nicotinic acetylcholine receptors." Biochemistry. 2009; 48(51): 12329-36. PubMed: 19899809
| Comments:Residues 32-68 and 118-156 encompassing each TM domain are predicted to be ordered.
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| References |
- Ben-Ami HC, Yassin L, Farah H, Michaeli A, Eshel M, Treinin M. "RIC-3 affects properties and quantity of nicotinic acetylcholine receptors via a mechanism that does not require the coiled-coil domains." J Biol Chem. 2005; 280(30): 28053-60. PubMed: 15932871
- Biala Y, Liewald JF, Ben-Ami HC, Gottschalk A, Treinin M. "The conserved RIC-3 coiled-coil domain mediates receptor-specific interactions with nicotinic acetylcholine receptors." Mol Biol Cell. 2009; 20(5): 1419-27. PubMed: 19116311
- Halevi S, McKay J, Palfreyman M, Yassin L, Eshel M, Jorgensen E, Treinin M. "The C. elegans ric-3 gene is required for maturation of nicotinic acetylcholine receptors." EMBO J. 2002; 21(5): 1012-20. PubMed: PMC125878
- Halevi S, Yassin L, Eshel M, Sala F, Sala S, Criado M, Treinin M. "Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression." J Biol Chem. 2003; 278(36): 34411-7. PubMed: 12821669
- Shteingauz A, Cohen E, Biala Y, Treinin M. "The BTB-MATH protein BATH-42 interacts with RIC-3 to regulate maturation of nicotinic acetylcholine receptors." J Cell Sci. 2009; 122(6): 807-12. PubMed: 19223395
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| Comments |
[AV 05/24/2010 PMID 19899809]
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